Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Boehringer Ingelheim | INDUSTRY |
Not provided
Not provided
Not provided
To study the effect of radiocontrast material on kidney functions in diabetics with microalbuminuria
Study design:
This study will be an observational prospective cohort study.
Study population:
Diabetics undergoing any intervention using radiocontrast material for any medical indication in Fayoum universiy hospital will be selected. There will be two arms of the study,each arm will contain 20 patients first arm diabetics on linagelptin, second arm diabetics on other DPP4 inhibitors.
Data collection:
Patients will be subjected to; full clinical examination,waist hip ratio assessment,BMI assessment fasting blood glucose,Serum uric acid, urine ACR, eGFR will be done before and after the investigation.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| diabetics on linagelptin | Diabetic patients were given linagelptin for blood glucose control |
| |
| diabetics on other DPP4 inhibitors | Diabetic pateints were given other DPP4 inhibitors eg: vlidagliptin for blood glucose control |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Linagliptin Oral Tablet | Drug | Linagliptin for blood glucose control |
|
| Measure | Description | Time Frame |
|---|---|---|
| affection of estimated glomerular filtration rate | A significant decrease in estimated glomerular filtration rate (eGFR) | Two months |
| Measure | Description | Time Frame |
|---|---|---|
| change in serum uric acid | A significant rise in serum uric acid | Two months |
| Measure | Description | Time Frame |
|---|---|---|
| Affection of albumin creatinine ratio | A significant increase in albumin creatinine ratio in urine (ACR) | Two months |
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Diabetics undergoing any intervention using radiocontrast material for any medical indication in Fayoum university hospital will be selected.
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Usama A Sharafeldin, MD | Cairo University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of medicine Fayoum univesity | Al Fayyum | Egypt | ||||
| Fayoum University |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36974638 | Derived | Fayed A, Hammad AA, Abdulazim DO, Hammad H, Amin M, Elhadidy S, Salem MM, ElAzim IMA, Zsom L, Csongradi E, Soliman KM, Sharaf El Din UA. Is the combination of linagliptin and allopurinol better prophylaxis against post-contrast acute kidney injury? A multicenter prospective randomized controlled study. Ren Fail. 2023 Dec;45(1):2194434. doi: 10.1080/0886022X.2023.2194434. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D000069476 | Linagliptin |
| ID | Term |
|---|---|
| D011687 | Purines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
Not provided
Not provided
Not provided
Not provided
Not provided
| Al Fayyum |
| Egypt |
| D011799 | Quinazolines |