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| Name | Class |
|---|---|
| Turkish Society of Anesthesiology and Reanimation | OTHER |
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The aim of this study is to describe the transfusion practices in patients undergoing major surgery in Turkey. The transfusion rates of red blood cells (RBC), fresh frozen plasma (FFP) and platelets; the transfusion predictors and transfusion related patient outcomes are investigated.
Patient Blood Management (PBM) is an evidence based multidisciplinary approach for the care of patients who may need blood transfusion. The aim of PBM is achieving better patient outcomes by focusing on the patients' own blood as a source.
To date PBM is considered "good transfusion practice" and is being implemented in a growing number of countries. The Turkish Society of Anesthesiologists PBM Task Force is working on this subject since 4 years and decided to conduct a study. Before starting a PBM program, the transfusion practices of clinicians working at diverse surgical fields; differences between current transfusion practices and PBM strategies; the areas for improvement and the obstacles that could prevent change could be identified with this study. Data collection will also serve to identify the current situation as a reference and to control the achievement of the PBM's aim: improving clinical outcomes. These data will be refered as The Turkish National Perioperative Transfusion Study (TULIP TS) data.
The aim of this study is to describe the transfusion practices in patients undergoing major surgery in Turkey.
The study evaluates i. The perioperative transfusion rates of RBCs, FFP and platelets. ii. With which reasons the anesthesiologists decide to transfuse a patient (co morbidities of the patients, physiologic transfusion triggers, hemoglobin trigger, uncontrolled bleeding, on request from surgeon etc.).
iii. The relation of transfusion and the patients co-morbidity index, the P POSSUM score and SORT score; anesthesia methods; monitorisation methods (hemodynamic, coagulation); amount of bleeding; type of surgery; type of hospital.
iv. The relation of transfusion and patient outcomes (unanticipated ICU admission, prolonged ICU stay, acute renal failure, thromboembolic events, ischemic events, pulmonary complications, cardiac advers events, infections, acute respiratory distress, infection, all-cause mortality).
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood transfusion | Other | Transfusion of blood products in the perioperative period in patients undergoing major surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Preoperative amount of blood products transfused | Preoperative amount of blood products: RBCs,FFP and platelets transfused | Before surgery at day 0 |
| Intraoperative amount of blood products transfused | Intraoperative amount of blood products: RBC's,FFP and platelets transfused | During surgery at day 0 |
| Postoperative amount of blood products transfused | Postoperative amount of blood products: RBCs,FFP and platelets transfused | 24 hours after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Preoperative transfusion indications | The reasons to decide to transfuse (factors determining transfusion) blood products | Before surgery at day 0 |
| Intraoperative transfusion indications | The reasons to decide to transfuse (factors determining transfusion) blood products |
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Inclusion Criteria:
Patients undergoing major elective surgery
Exclusion Criteria:
Trauma patients, emergency surgery
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Patients undergoing major elective surgery in General surgery Orthopedics Urology Transplantation surgery Neurosurgery Gynecology and obstetrics Cardiovascular surgery
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| Name | Affiliation | Role |
|---|---|---|
| Dilek Unal, Assoc Prof | Netherlands: Ministry of Health, Welfare and Sports | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Acibadem University Mehmet Ali Aydinlar Atakent Hospital | Ankara | Turkey (Türkiye) | ||||
| Ankara University Cebeci Medical Center |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22593128 | Background | Kotze A, Carter LA, Scally AJ. Effect of a patient blood management programme on preoperative anaemia, transfusion rate, and outcome after primary hip or knee arthroplasty: a quality improvement cycle. Br J Anaesth. 2012 Jun;108(6):943-52. doi: 10.1093/bja/aes135. | |
| 26787795 | Background | Meier J, Filipescu D, Kozek-Langenecker S, Llau Pitarch J, Mallett S, Martus P, Matot I; ETPOS collaborators. Intraoperative transfusion practices in Europe. Br J Anaesth. 2016 Feb;116(2):255-61. doi: 10.1093/bja/aev456. |
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| During surgery at day 1 |
| Postoperative transfusion indications | The reasons to decide to transfuse (factors determining transfusion) blood products | 24 hours after surgery |
| Unanticipated ICU admission | Whether the patient had an unanticipated ICU admission | After surgery at day 1 |
| Prolonged length of stay in ICU | Whether the patient had a prolonged length of stay in ICU | After surgery at day 2 |
| Acute renal failure | Whether the patient had acute renal failure | After surgery at day 2 |
| Thromboembolic event | Whether the patient had a thromboembolic event concerning lungs (pulmonary embolism), brain (stroke), gastrointestinal tract, kidneys, or extremities etc. | After surgery at day 2 |
| Ischemic event | Whether the patient had an ischemic event concerning heart, nervous system,limb, gastrointestinal tract etc. | After surgery at day 2 |
| Infection | Whether the patient had infection: wound, pneumonia, urinary, sepsis etc. | After surgery at day 2 |
| Acute respiratory distress | Whether the patient had acute respiratory distress | After surgery at day 2 |
| Mortality | Whether the patient died: all cause mortality | after surgery at day 30 |
| Preoperative anemia | Whether the patient had anemia (Hemoglobin male < 13 female < 12 g/dL) | Before surgery at day 0 |
| Preoperative coagulopathy | Whether the patient had coagulopathy due to disease or drugs | Before surgery at day 0 |
| Pretransfusion hemoglobin values | The hemoglobin concentration before transfusion | Before surgery at day 0 |
| Pretransfusion hemoglobin values | The hemoglobin concentration before transfusion | During surgery at day 1 |
| Pretransfusion hemoglobin values | The hemoglobin concentration before transfusion | After surgery at day 2 |
| Advers cardiac events | Whether the patient had an advers cardiac event: myocardial infaction; non fatal cardiac arest; arrhytmia; cardiogenic pulmonary edema etc | After surgery at day 30 |
| Ankara |
| Turkey (Türkiye) |
| Ankara University Ibni Sina Hospital | Ankara | Turkey (Türkiye) |
| Başkent University Ankara Hospital | Ankara | Turkey (Türkiye) |
| Gazi University Medical Faculty | Ankara | Turkey (Türkiye) |
| Hacettepe University Medical Faculty | Ankara | Turkey (Türkiye) |
| Private Cankaya Hospital | Ankara | Turkey (Türkiye) |
| Ufuk University Medical Faculty Dr. Ridvan Ege Training and Research Hospital | Ankara | Turkey (Türkiye) |
| University of Health sciences Ankara Child Health and Diseases Hematology Oncology Training and research Hospital | Ankara | Turkey (Türkiye) |
| University of Health Sciences Ankara Numune Training and Research Hospital | Ankara | Turkey (Türkiye) |
| University of Health Sciences Ankara Training and Research Hospital | Ankara | Turkey (Türkiye) |
| University of Health Sciences Diskapi Yildirim Beyazit Trainig Research Hospital | Ankara | Turkey (Türkiye) |
| University of Health Sciences Dr Abdurrahman Yurtaslanı Ankara Oncology Training and Research Hospital | Ankara | Turkey (Türkiye) |
| University of Health Sciences Kecioren Training and Research Hospital | Ankara | Turkey (Türkiye) |
| University of Health Sciences Turkiye Yuksek Ihtisas Training and Research Hospital | Ankara | Turkey (Türkiye) |
| University of Health Sciences Yenimahalle Training and Research Hospital | Ankara | Turkey (Türkiye) |
| University of Health Sciences Zubeyde Hanim Gynecology and Maternity Training and Research Hospital | Ankara | Turkey (Türkiye) |
| University of Technology and Economics Medical Faculty | Ankara | Turkey (Türkiye) |
| Akdeniz University Medical Faculty | Antalya | Turkey (Türkiye) |
| University of Health Sciences Antalya Training and Research Hospital | Antalya | Turkey (Türkiye) |
| Balikesir University Training and Research Hospital | Balıkesir | Turkey (Türkiye) |
| Uludağ University Medical Faculty | Bursa | Turkey (Türkiye) |
| University of Health Sciences Bursa Yuksek Ihtisas Training and Research Hospital | Bursa | Turkey (Türkiye) |
| Hitit University Corum Erol Olcok Training and Research Hospital | Çorum | Turkey (Türkiye) |
| Trakya University Medical Faculty | Edirne | Turkey (Türkiye) |
| Fırat University Medical Faculty | Elâzığ | Turkey (Türkiye) |
| Erzincan University Mengucek Gazi Training and Research Hospital | Erzincan | Turkey (Türkiye) |
| Eskisehir Osmangazi University Medical Faculty | Eskişehir | Turkey (Türkiye) |
| Suleyman Demirel University Medical Faculty | Isparta | Turkey (Türkiye) |
| Acibadem University Altunizade Hospital | Istanbul | Turkey (Türkiye) |
| Istanbul Medeniyet University Goztepe Training and Research Hospital | Istanbul | Turkey (Türkiye) |
| Istanbul University Medical Faculty | Istanbul | Turkey (Türkiye) |
| Marmara University Pendik Training and Research Hospital | Istanbul | Turkey (Türkiye) |
| University of Health Sciences Fatih Sultan Mehmet Training and Research Hospital | Istanbul | Turkey (Türkiye) |
| University of Health Sciences Haydarpasa Numne Training and Research Hospital | Istanbul | Turkey (Türkiye) |
| University of Health Sciences Istanbul Training and Research Hospital | Istanbul | Turkey (Türkiye) |
| University of Health Sciences Kanuni Sultan Suleyman Training and Research Hospital | Istanbul | Turkey (Türkiye) |
| University of Health Sciences Okmeydanı Training and Research Hospital | Istanbul | Turkey (Türkiye) |
| University of Health Sciences Umraniye Training and Research Hospital | Istanbul | Turkey (Türkiye) |
| Dokuz Eylul University Medical Faculty | Izmir | Turkey (Türkiye) |
| University of Health Sciences Bozyaka Training Research Hospital | Izmir | Turkey (Türkiye) |
| University of Health Sciences İzmir Tepecik Training and Research Hospital | Izmir | Turkey (Türkiye) |
| Sutcu Imam University Medical Faculty | Kahramanmaraş | Turkey (Türkiye) |
| Erciyes University Medical Faculty | Kayseri | Turkey (Türkiye) |
| University of Health Sciences Kayseri Training and Research Hospital | Kayseri | Turkey (Türkiye) |
| Anadolu Health Center Hospital | Kocaeli | Turkey (Türkiye) |
| University of Health Sciences Derince Training and Research Hospital | Kocaeli | Turkey (Türkiye) |
| Necmettin Erbakan University Meram Medical Faculty Center for Health and Research | Konya | Turkey (Türkiye) |
| Selcuk University Medical Faculty | Konya | Turkey (Türkiye) |
| University of Health Sciences Konya Training and Research Hospital | Konya | Turkey (Türkiye) |
| Inonu University Liver Transplantation Institute | Malatya | Turkey (Türkiye) |
| Manisa Celal Bayar University Medical Faculty Hafsa Sultan Hospital | Manisa | Turkey (Türkiye) |
| Mersin University Medical Faculty | Mersin | Turkey (Türkiye) |
| Ordu University Medical Faculty | Ordu | Turkey (Türkiye) |
| Osmaniye State Hospital | Osmaniye | Turkey (Türkiye) |
| Ondokuz Mayıs University Medical Faculty | Samsun | Turkey (Türkiye) |
| Namık Kemal University Medical Faculty | Tekirdağ | Turkey (Türkiye) |
| Karadeniz Technical University Medical Faculty Farabi Hospital | Trabzon | Turkey (Türkiye) |
| Tunceli State Hospital | Tunceli | Turkey (Türkiye) |
| Van Yuzuncuyıl University Medical Faculty Dursun Odabası Center | Van | Turkey (Türkiye) |
| Bulent Ecevit University Medical Faculty Center for Health and Research | Zonguldak | Turkey (Türkiye) |
| 17998460 | Background | Murphy GJ, Reeves BC, Rogers CA, Rizvi SI, Culliford L, Angelini GD. Increased mortality, postoperative morbidity, and cost after red blood cell transfusion in patients having cardiac surgery. Circulation. 2007 Nov 27;116(22):2544-52. doi: 10.1161/CIRCULATIONAHA.107.698977. Epub 2007 Nov 12. |
| 9699234 | Background | Hsieh FY, Bloch DA, Larsen MD. A simple method of sample size calculation for linear and logistic regression. Stat Med. 1998 Jul 30;17(14):1623-34. doi: 10.1002/(sici)1097-0258(19980730)17:143.0.co;2-s. |
| 20642690 | Background | Kalil AC, Mattei J, Florescu DF, Sun J, Kalil RS. Recommendations for the assessment and reporting of multivariable logistic regression in transplantation literature. Am J Transplant. 2010 Jul;10(7):1686-94. doi: 10.1111/j.1600-6143.2010.03141.x. |
| ID | Term |
|---|---|
| D016063 | Blood Loss, Surgical |
| D000740 | Anemia |
| D020141 | Hemostatic Disorders |
| ID | Term |
|---|---|
| D006470 | Hemorrhage |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007431 | Intraoperative Complications |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D006474 | Hemorrhagic Disorders |
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| ID | Term |
|---|---|
| D001803 | Blood Transfusion |
| ID | Term |
|---|---|
| D001691 | Biological Therapy |
| D013812 | Therapeutics |
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