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A study of two ventilatory strategies for low tidal volume ventilation compared to a control group to elucidate if low tidal volumes of 3ml/kg or 4ml/kg were feasible for one lung ventilation.
This study investigated the feasibility of low tidal volume ventilation for one lung ventilation.
45 patients were recruited - 15 patients in each of three groups, 3ml/kg, 4ml/kg or usual care.
Outcomes studied were length of stay, 30 day mortality, unplanned ICU admission, evidence of respiratory failure or requirement for non-invasive ventilation, chest x-ray infiltrates and requirement for antibiotics.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 3ml/kg | Active Comparator | 15 patients ventilated with 3ml/kg ideal body weight while on one lung ventilation |
|
| 4ml/kg | Active Comparator | 15 patients ventilated with 4ml/kg ideal body weight while on one lung ventilation |
|
| control | Active Comparator | 15 patients ventilated using the anaesthetists usual ventilation strategy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| tidal volume ventilation | Procedure | low tidal volume ventilation |
|
| Measure | Description | Time Frame |
|---|---|---|
| Radiological evidence of injury to the ventilated lung | evidence of infiltrates in the non operative lung | post operatively up to 6 weeks post operatively |
| unplanned ICU admission | unplanned admission to the icu with respiratory issues | up to 6 weeks post operatively |
| Requirement for non-invasive ventilation | whether a patient in the trial requires niv for respiratory failure | up to 6 weeks post operatively |
| Hospital acquired pneumonia | pneumonia acquired in hospital | up to discharge at 6 weeks post operatively |
| Measure | Description | Time Frame |
|---|---|---|
| length of hospital stay | number of days in hospital | until patient discharge at 6 weeks post operatively |
| length of icu stay | number of days in ICU |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ignacio Martin-Loeches, md | University of Dublin, Trinity College | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| St James's Hospital Dublin | Dublin | Ireland |
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parallel assignment
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open label, randomisation blinded
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| until patient discharge at 6 weeks post operatively |
| 30 day mortality | number of patients who died within 30 days of their procedure | 30 days post operatively |