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The purpose of this clinical study is to collect baseline information on dietary habits and metabolic risk factors, and to examine the effects of a dietary intervention focusing on fiber and antioxidant rich berries on the development of gestational diabetes, maternal glucose and lipid control and inflammation in obese pregnant women at risk of developing diabetes. With the ongoing epidemic of obesity, the prevalence of gestational diabetes is significantly increasing and the goal of this research is to identify optimal dietary strategies that can reverse this condition or control the rise in blood glucose among those with already developed diabetes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Prenatal Care/Nutrition Education | No Intervention | Participants were given nutrition educational counseling on healthy dietary habits and gestational weight gain as part of standard prenatal care. | |
| Dietary Intervention | Experimental | Participants were given dietary blueberries (2 cups) and soluble fiber (12g). They also received nutrition educational counseling on healthy dietary habits and gestational weight gain as part of standard prenatal care. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blueberry + soluble fiber | Dietary Supplement | Dietary frozen blueberries and soluble fiber for 20 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| Gestational weight gain | Maternal weight gain in lbs | 20 weeks |
| Gestational glycemia | Maternal blood glucose and HbA1c as measures of glycemia | 20 weeks |
| Maternal serum lipids | Conventional total, LDL-cholesterol and their particle size to describe lipid profiles | 20 weeks |
| Maternal inflammation | C-reactive protein as a stable biomarker of inflammation | 20 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Maternal biomarkers of atherosclerosis | Serum cytokines measured as interleukins and adipokines | 20 weeks |
| Maternal dietary intakes | Maternal intakes of energy intake and nutrients |
| Measure | Description | Time Frame |
|---|---|---|
| Maternal metabolomics | Maternal serum NMR metabolites | 20 weeks |
Inclusion Criteria:
Exclusion Criteria:
• Twin or multiple pregnancy
Pregnancy study
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| Name | Affiliation | Role |
|---|---|---|
| Arpita Basu, PhD | University of Nevada at Las Vegas | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Nevada at Las Vegas | Las Vegas | Nevada | 89154 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33693835 | Derived | Basu A, Feng D, Planinic P, Ebersole JL, Lyons TJ, Alexander JM. Dietary Blueberry and Soluble Fiber Supplementation Reduces Risk of Gestational Diabetes in Women with Obesity in a Randomized Controlled Trial. J Nutr. 2021 May 11;151(5):1128-1138. doi: 10.1093/jn/nxaa435. |
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| ID | Term |
|---|---|
| D016640 | Diabetes, Gestational |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D003920 | Diabetes Mellitus |
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| ID | Term |
|---|---|
| C000721609 | blueberry extract |
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| 20 weeks |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |