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Comparative retrospective study of two anal canal brachytherapy techniques aimed at boosting [low dose rate (LDR) and high dose rate (HDR)]
Efficacy of anal canal interstitial brachytherapy evaluated by local relapse rate, Tolerance of interstitial brachytherapy of the anal canal evaluated by the rate of chronic toxicities.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Low Dose Rate | Patients treated with brachytherapy at low dose rate of the anal canal with aim of boost |
| |
| High Dose Rate | Patients treated by brachytherapy with a high dose rate of the anal canal aiming for boost |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Brachytherapy | Radiation | Brachytherapy |
|
| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of the efficacy of interstitial brachytherapy of the anal canal | Efficacy of anal canal interstitial brachytherapy evaluated by local relapse rate | 1 year |
| Evaluation of the tolerance of interstitial brachytherapy of the anal canal | Tolerance of interstitial brachytherapy of the anal canal evaluated by the rate of chronic toxicities. | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Estimation of local control | Local control defined as the time between the date of diagnosis and the date of local relapse or death or recent news | 1 year |
| Estimation of disease free survival | Disease free survival defined as the delay between the date of diagnosis and the date of local or locoregional or distant relapse or death or recent news |
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Inclusion Criteria:
Exclusion Criteria:
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Patients treated with anal canal brachytherapy for boost, between 2008 and 2016.
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| Name | Affiliation | Role |
|---|---|---|
| Leonel VARELA GAGETTI | Institut Paoli-Calmettes | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institut Paoli Calmettes | Marseille | Bouches Du Rhone | 13009 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27600606 | Result | Cordoba A, Escande A, Leroy T, Mirabel X, Coche-Dequeant B, Lartigau E. Low-dose-rate interstitial brachytherapy boost for the treatment of anal canal cancers. Brachytherapy. 2017 Jan-Feb;16(1):230-235. doi: 10.1016/j.brachy.2016.07.007. Epub 2016 Sep 3. | |
| 25935731 | Result | Boukhelif W, Ferri-Molina M, Mazeron R, Maroun P, Duhamel-Oberlander AS, Dumas I, Martinetti F, Guemnie-Tafo A, Chargari C, Haie-Meder C. Interstitial pulsed-dose-rate brachytherapy for the treatment of squamous cell anal carcinoma: A retrospective single institution analysis. Brachytherapy. 2015 Jul-Aug;14(4):549-53. doi: 10.1016/j.brachy.2015.03.006. Epub 2015 Apr 29. |
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| ID | Term |
|---|---|
| C563020 | Anal Canal Carcinoma |
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| ID | Term |
|---|---|
| D001918 | Brachytherapy |
| ID | Term |
|---|---|
| D011878 | Radiotherapy |
| D013812 | Therapeutics |
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| 1 year |
| Estimation of overall survival | Overall survival defined as the time between the date of diagnosis and the date of death or latest news | 1 year |
| Comparison of the incidence of toxicities (CTCAE v4) between the 2 groups | rate of toxicities | 1 year |