Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This study evaluates psychophysical measures of pain inhibition and facilitation, along with cortical responses to different sensory stimuli, in patients with recurrent low back pain and matched healthy individuals.
Pain inhibitory and facilitatory mechanisms have been suggested to play a role in the development of persistent low back pain; however, there is still debate on when changes in these mechanisms occur. Similarly, evoked cortical responses can reflect neuroplastic changes in pain processing regions, which are also thought to play a role in the transition to persistent pain, but there is also debate on when these neuroplastic changes develop relative to low back pain. Therefore, this study will use patients with an intermediary clinical pain state, recurrent low back pain, and matched healthy control participants, to investigate within and between subject differences in pain inhibitory, facilitatory and neuroplastic mechanisms.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Recurrent Low Back Pain Patients | Participants experiencing a current episode of their recurrent non-specific low back pain at the time of recruitment. | ||
| Healthy Volunteers | Participants matched in age and gender to one of the recurrent low back pain patients, with no significant past low back pain, chronic pain or other relevant medical disorders. |
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Conditioned Pain Modulation | Pressure pain threshold (kPa) as test stimulus before compared to during a pressure conditioning stimulus on the lower leg | Day 0 vs. Day 28 |
| Temporal Summation of Pain | Pain rating (VAS) change over a series of 10 repeated mechanical stimuli | Day 0 vs. Day 28 |
| Measure | Description | Time Frame |
|---|---|---|
| Pressure Pain Thresholds | Threshold of pain detection (kPa) with handheld algometry over the low back and distant sites | Day 0 vs. Day 28 |
| Thermal Pain Thresholds | Hot and cold pain detection thresholds (degrees) |
| Measure | Description | Time Frame |
|---|---|---|
| Affective Regulation | Pressure pain ratings pre, during and post affective image set | Day 0 vs. Day 28 |
| Attentional Regulation | Pressure pain ratings pre, during and post computerised attention-demanding task |
Inclusion:
Exclusion:
Not provided
Not provided
Population recruited from university, college, and wider Aalborg community
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Megan E McPhee, BPhty MSc | Aalborg University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CNAP, SMI, Aalborg University | Aalborg | 9000 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34382603 | Derived | McPhee ME, Graven-Nielsen T. Positive affect and distraction enhance whereas negative affect impairs pain modulation in patients with recurrent low back pain and matched controls. Pain. 2022 May 1;163(5):887-896. doi: 10.1097/j.pain.0000000000002442. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D017116 | Low Back Pain |
| ID | Term |
|---|---|
| D001416 | Back Pain |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
Not provided
Not provided
Not provided
Not provided
Not provided
| Day 0 vs. Day 28 |
| Two Point Discrimination | The smallest distance (mm) for which two separate points can be distinguished over the low back | Day 0 vs. Day 28 |
| Proprioceptive Weighting | Center of pressure displacement during 1-minute of quiet standing | Day 0 vs. Day 28 |
| Sensory Evoked Potentials | EEG signals recorded in response to laser and electrical stimuli applied to the back | Day 0 vs. Day 28 |
| Day 0 vs. Day 28 |
| D013568 |
| Pathological Conditions, Signs and Symptoms |