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A prospective randomized study included 210 women with Unexplained infertility subjected to combined ovarian stimulation and Intrauterine insemination (IUI). Two equal groups. Study group, subjected to uterine flushing with Human chorionic gonadotropin (HCG) one day before IUI and control group subjected to IUI alone.
A prospective randomized study included 210 patients with Unexplained infertility subjected to coupled ovarian stimulation and Intrauterine insemination (IUI). Two equal groups. Study group, subjected to uterine flushing with Human chorionic gonadotropin (HCG) one day before IUI and control group subjected to IUI alone.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HCG uterine flushing group | Active Comparator | Uterine flushing was done one day before Intrauterine insemination (IUI) with HCG (500 IU) in 10 ml of saline followed by Intrauterine insemination (IUI). |
|
| IUI alone group | Placebo Comparator | Intrauterine insemination alone plus vaginal flushing with 10 ml normal saline |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| HCG Uterine flushing | Procedure | HCG Uterine flushing was done one day before IUI with HCG (500 IU) in 10 ml of saline. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Live birth | Defined as pregnancies maintained beyond 20 weeks of gestation | 10 months of randomization |
| Measure | Description | Time Frame |
|---|---|---|
| Chemical pregnancy | Defined as positive serum pregnancy test | One month after randomization |
| Clinical pregnancy | Defined by the presence of gestational sac with fetal heartbeats on ultrasound scan or histological identification of trophoblastic tissue. |
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Inclusion Criteria:
Exclusion Criteria:
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| ID | Term |
|---|---|
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |
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intrauterine injection of human chorionic gonadotropin before intrauterine insemination (IUI) compared to IUI alone
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Vaginal flushing with 10 ml saline was performed in the control group
| IUI | Procedure | Intrauterine insemination (IUI) |
|
| Vaginal flushing with 10 ml normal saline | Procedure | Flushing of the vagina with 10 ml of saline |
|
| Two months after randomization |
| Adverse effects | Nausea, vomiting, and pain | one hour of the procedure |