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The aim of this study is to investigate the most effective stimulation site in transcranial direct current stimulation for gait recovery after stroke. All subjects will go through four conditions of transcranial direct current stimulation with for 30 minutes. Four conditions are 1) bihemispheric stimulation - anodal stimulation on both ipsilesional and contralesional leg area of primary motor cortex and supplementary motor area. 2) ipsilesional stimulation - anodal stimulation on ipsilesional leg area of primary motor cortex and supplementary motor area. 3) contralesional stimulation - anodal stimulation on contralesional leg area of primary motor cortex and supplementary motor area. 4) sham stimulation. Subjects will walk on treadmill for 10 minutes during transcranial direct current stimulation. Motor evoked potential and functional evaluations will be done before and after stimulation to measure the changes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Bihemispheric stimulation | Experimental |
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| Ipsilesional stimulation | Experimental |
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| Contralesional stimulation | Experimental |
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| Sham | Active Comparator |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ipsilesional stimulation | Device | anodal stimulation on Ipsilesional leg area of primary motor cortex and supplementary motor area for 30 minutes |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in motor evoked potential | measure the motor threshold and amplitude of motor evoked potential in tibialis anterior muscle. | before and after intervention (approximately 30 minutes) |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in motricity index | measures motor function | before and after intervention (approximately 30 minutes) |
| Changes in Fugl Meyer Assessment | Fugl Meyer Assessment is a measurement of motor function. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Samsung Medical Center | Seoul | South Korea |
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| ID | Term |
|---|---|
| D020521 | Stroke |
| D020233 | Gait Disorders, Neurologic |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| Contralesional stimulation | Device | anodal stimulation on contralesional leg area of primary motor cortex and supplementary motor area for 30 minutes |
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| Walking on treadmill | Other | walking on treadmill for 10 minutes |
|
| before and after intervention (approximately 30 minutes) |
| Changes in 10 meter walking test | measures gait speed | before and after intervention (approximately 30 minutes) |
| Timed up and go test | measures gait capacity and balance | before and after intervention (approximately 30 minutes) |
| Functional ambulatory category | measure gait ability. 0 is impossible to gait and 6 is normal. | before and after intervention (approximately 30 minutes) |
| Modified ashworth scale | measures spasticity with scale from 0 to 3. 0 is no increase in muscle tone. 3 is considerable increase in muscle tone, passive movement difficult. | before and after intervention (approximately 30 minutes) |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |