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The study evaluates whether sarcopenia influences the prevalence of abdominal hernias in patients with cirrhosis.
Sarcopenia is a common condition in patients with cirrhosis, with a prevalence of around 50%. It is unknown if the presence of sarcopenia may influence the prevalence of abdominal hernias in this group of patients. Clinical, nutritional and radiological evaluation will be performed in two groups of cirrhotic patients to evaluate this hypothesis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 | This group consists of cirrhotic patients with any abdominal hernia |
| |
| Group 2 | This group consists of cirrhotic patients without any hernias |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Computed Tomography Scan | Diagnostic Test | The results of the CT scan and the hand-grip test will be used for diagnosis of sarcopenia. The Royal Free Hospital-Global Assessment (RFH-GA) results will classify the nutritional status of the patient. |
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of Sarcopenia | Prevalence of Sarcopenia in patients with cirrhosis | Through study completion (an average of 1 year) |
| Influence of Sarcopenia in Prevalence of Abdominal Hernias in Patients with Cirrhosis | Influence of Sarcopenia in Prevalence of Abdominal Hernias in Patients with Cirrhosis | Through study completion (an average of 1 year) |
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Inclusion Criteria:
Exclusion Criteria:
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Tertiary care adult patients with cirrhosis, with and without abdominal hernias.
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| Name | Affiliation | Role |
|---|---|---|
| Alberto Meyer, PhD | Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital das ClÃnicas da Faculdade de Medicina da Universidade de São Paulo | São Paulo | São Paulo | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25009378 | Background | Montano-Loza AJ. Clinical relevance of sarcopenia in patients with cirrhosis. World J Gastroenterol. 2014 Jul 7;20(25):8061-71. doi: 10.3748/wjg.v20.i25.8061. | |
| 26139982 | Background | Kalafateli M, Konstantakis C, Thomopoulos K, Triantos C. Impact of muscle wasting on survival in patients with liver cirrhosis. World J Gastroenterol. 2015 Jun 28;21(24):7357-61. doi: 10.3748/wjg.v21.i24.7357. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Mar 4, 2022 | |
| Reset | May 19, 2022 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Mar 4, 2022 | May 19, 2022 |
| ID | Term |
|---|---|
| D005355 | Fibrosis |
| D055948 | Sarcopenia |
| D044342 | Malnutrition |
| D046449 | Hernia, Abdominal |
| D006552 | Hernia, Inguinal |
| D006554 | Hernia, Umbilical |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
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| ID | Term |
|---|---|
| D014057 | Tomography, X-Ray Computed |
| ID | Term |
|---|---|
| D007090 | Image Interpretation, Computer-Assisted |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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|
| 17006918 | Background | Morgan MY, Madden AM, Soulsby CT, Morris RW. Derivation and validation of a new global method for assessing nutritional status in patients with cirrhosis. Hepatology. 2006 Oct;44(4):823-35. doi: 10.1002/hep.21358. |
| 20392703 | Background | Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, Schneider SM, Topinkova E, Vandewoude M, Zamboni M; European Working Group on Sarcopenia in Older People. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing. 2010 Jul;39(4):412-23. doi: 10.1093/ageing/afq034. Epub 2010 Apr 13. |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D012816 | Signs and Symptoms |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D006547 | Hernia |
| D007232 | Infant, Newborn, Diseases |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D006555 | Hernia, Ventral |
| D011856 | Radiographic Image Enhancement |
| D007089 | Image Enhancement |
| D010781 | Photography |
| D011859 | Radiography |
| D014056 | Tomography, X-Ray |
| D014054 | Tomography |