RIPC and Platelet Activation on Platelet Activation During Cardiopulmonary Bypass

Effect of Remote Ischemic Preconditioning on Platelet Activation During Cardiac Surgery With Cardiopulmonary Bypass

In this study, the investigators are going to investigate the effects of remote ischemic preconditioning on platelet activation in patients undergoing cardiac surgery with cardiopulmonary bypass.

Previous studies reported that remote ischemic conditioning reduce platelet activation in patients with coronary artery disease or patients undergoing ablation for atrial fibrillation. Cardiac surgery with cardiopulmonary bypass has been associated with platelet activation. In this randomized study, investigators are going to compare the effects of remote ischemic preconditioning (RIPC) on platelet activation using flow cytometry in patients undergoing cardiac surgery with cardiopulmonary bypass.

Inclusion Criteria:

• Patients undergoing cardiac surgery with cardiopulmonary bypass

Exclusion Criteria:

• Preoperative left ventricle ejection fraction < 30%, mechanical ventricular support
• Peripheral vascular disease
• Poorly controlled diabetes mellitus
• NSAIDs within 3 days
• iv heparin within 6 h
• low molecular weight heparin within 24 h
• platelet inhibitor within 24 h
• known thrombocytopenia
• End stage renal disease / hemodialysis
• Active infection
• Pregnancy