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In this study, the investigators are going to investigate the effects of remote ischemic preconditioning on platelet activation in patients undergoing cardiac surgery with cardiopulmonary bypass.
Previous studies reported that remote ischemic conditioning reduce platelet activation in patients with coronary artery disease or patients undergoing ablation for atrial fibrillation. Cardiac surgery with cardiopulmonary bypass has been associated with platelet activation. In this randomized study, investigators are going to compare the effects of remote ischemic preconditioning (RIPC) on platelet activation using flow cytometry in patients undergoing cardiac surgery with cardiopulmonary bypass.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Remote ischemic preconditioning | Active Comparator | Remote ischemic conditioning after anesthesia induction - four cycles of 5 min of ischemia followed by 5 min of reperfusion by inflation to 200 mm Hg and deflation of a blood pressure cuff on the upper arm |
|
| Sham control | Sham Comparator | The same blood pressure cuff is placed around the upper arm, but the cuff is inflated to 10mm Hg. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Remote ischemic preconditioning | Device | Four cycles of 5 min of ischemia, which is induced by a blood pressure cuff in the upper arm inflated to 200 mmHg, followed by 5 min of reperfusion, during which the cuff is deflated. |
| Measure | Description | Time Frame |
|---|---|---|
| Platelet activation measured by CD62P expression using flow cytometry | CD62P AUC (area under the curve) | During 3hour after cardiopulmonary bypass initiation |
| Measure | Description | Time Frame |
|---|---|---|
| Platelet activation measured by CD63 expression using flow cytometry | CD63 AUC (area under the curve) | During 3hour after cardiopulmonary bypass initiation |
| Platelet activation measured by monocyte-platelet aggregates (MPA) expression using flow cytometry |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Yunseok Jeon | Seoul National University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Seoul | 03080 | South Korea |
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| Sham control | Device | The same blood pressure cuff is placed around the upper arm, but the cuff is inflated to 10 mm Hg and ischemic preconditioning is not induced. |
|
MPA AUC (area under the curve) |
| During 3hour after cardiopulmonary bypass initiation |
| Platelet activation measured by PAC1 expression using flow cytometry | PAC1 AUC (area under the curve) | During 3hour after cardiopulmonary bypass initiation |
| Platelet activation measured by platelet microparticles (PMP) expression using flow cytometry | PMP AUC (area under the curve) | During 3hour after cardiopulmonary bypass initiation |
| ADPtest by Multiplate® platelet function analyser | ADPtest AU | 3hour after cardiopulmonary bypass initiation |
| ASPItest by Multiplate® platelet function analyser | ASPItest AU | 3hour after cardiopulmonary bypass initiation |
| COLtest by Multiplate® platelet function analyser | COLtest AU | 3hour after cardiopulmonary bypass initiation |