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The study will evaluate the clinical efficacy of midline catheters compared to conventional treatment in patients with an expected intravenous therapy duration of more than 5 days. Patients will be randomized in a 1:1 ratio. The study will include 120 patient. Endpoints include insertion of CVSs, peripheral venous catheters, catheter patency and a number of possible complications.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Midline | Active Comparator | Pt. will receive midline catheters. The outcomes will be registered and some patients will be examined once weekly for thrombosis with ultrasound. |
|
| Conventional | Active Comparator | Pt. will receive the conventional treatment (PVC and/or PICCline/CVC). The outcomes will be registered. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PVC and/or PICCline | Device | Pt. will receive PVC and/or PICCline |
|
| Measure | Description | Time Frame |
|---|---|---|
| Reducing the use of CVC and PVC | The fraction of patients requiring either a CVC - including PICC line - or require ≥ 4PVC insertions during the current admittance to the hospital, including follow-up intravenous therapy. | through study completion, an average of 7 month |
| Measure | Description | Time Frame |
|---|---|---|
| Bloodsamples from catheter | Registration of number of blood samples taken from the midline catheter | through study completion, an average of 7 month |
| Problems with catheter bloodsampling | Registration of aspiration problems during bloodsampling in midline catheters |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Emma Bundgaard, MS | Aarhus University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anaesthesiology and Intensive Care East Section, Aarhus University | Aarhus | 8000 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36507736 | Derived | Tada M, Yamada N, Matsumoto T, Takeda C, Furukawa TA, Watanabe N. Ultrasound guidance versus landmark method for peripheral venous cannulation in adults. Cochrane Database Syst Rev. 2022 Dec 12;12(12):CD013434. doi: 10.1002/14651858.CD013434.pub2. |
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60 patients in each group, with a total of 2 groups
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| Midline | Device | Pt. will receive midline |
|
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| through study completion, an average of 7 month |
| Bloodsamples (conventional) | Registration of number of blood samples taken from conventional blood samples in both groups | through study completion, an average of 7 month |
| Patient satisfaction | Patient satisfaction on NRS score, 0 is very unsatisfied and 10 is very satisfied | through study completion, an average of 7 month |
| Nurse satisfaction | Nurse satisfaction on NRS score, 0 is very unsatisfied and 10 is very satisfied | through study completion, an average of 7 month |
| Painscore | Accumulated NRS pain score for all IV catheter insertions. 0 is no pain and 10 is worst imaginable pain | through study completion, an average of 7 month |
| Rescue catherizations 1 | Rescue PVC's inserted (midline group) (no) | through study completion, an average of 7 month |
| Rescue catherizations 2 | Rescue central venous catheters including PICC line catheters inserted (no) | through study completion, an average of 7 month |
| Time consumption | Total time of cauterization, (measured from the entrance in patient room, to the exit) | through study completion, an average of 7 month |
| Catheter dwelltime | Time of catheter duration (hours) | through study completion, an average of 7 month |
| Fluid | Accumulated fluids infused (L) | through study completion, an average of 7 month |
| Treatment type | Type of medicine infused (all types) | through study completion, an average of 7 month |
| Treatment amount | Amount of medicine infused (L) | through study completion, an average of 7 month |
| Catheter related infections | Catheters removed due to suspected catheter-related infection (no) | through study completion, an average of 7 month |
| Thrombosis 1 | Thrombi visible at the catheter tip (no) | through study completion, an average of 7 month |
| Thrombosis 2 | Deep venous thrombosis of the ipsilateral arm (no) | through study completion, an average of 7 month |
| Thrombosis 3 | Superficial venous thrombosis of the ipsilateral arm (midline group) (no) | through study completion, an average of 7 month |
| Thrombosis 4 | Patients starting anti-thrombotic medicine due to thrombi generated by an IV catheter (no) | through study completion, an average of 7 month |
| Catheter discontinuation | Reasons for replacing catheters (all types) | through study completion, an average of 7 month |
| Insertion complication | Arterial punctures during catheter insertions (no) | through study completion, an average of 7 month |
| Insertion complication 2 | haematomas during catheter insertions (no) | through study completion, an average of 7 month |
| Insertion complication 3 | Misplaced catheters (no) | through study completion, an average of 7 month |
| Neuropraxia | Post-procedure median nerve palsy/neuropraxia (midline group) (no) | through study completion, an average of 7 month |