Precision Pain Management for Major Abdominal Surgery in Colorectal Surgery

Precision Pain Management for Major Abdominal Surgery in Colorectal Surgery

The primary objectives of this study are to evaluate the potential for preoperative pharmacogenomics (PGx) testing to positively influence postoperative opioid use through visual analog scale (VAS) guided administration of narcotic equivalent and lower pain scores as measured by OBAS in patients undergoing major abdominal surgery.

Inclusion Criteria:

• Subject capable of giving consent
• Age 18-80
• Scheduled for open colorectal resection at Cleveland Clinic main campus (with preoperative appointment scheduled at least five days before date of surgery)

Exclusion Criteria:

• Patient does not speak English
• Patient with substance-use disorder (including alcohol)
• Patient diagnosed with major depression
• Patient currently taking opioids
• Previous long-term opioid use (> 3 months)
• Previous opioid use with a dose of >100 milligram morphine equivalent (MME)
• Patient has pain-related disorder (e.g. fibromyalgia, sympathetic dystrophy, etc.)
• Documented allergy to pain medication