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| Name | Class |
|---|---|
| Edwards Lifesciences | INDUSTRY |
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The aim is to describe the physiological background for PLR and the interpretation of a PLR manoeuvre.
The protocol entails the measurement of stroke volume (SV) at baseline (semirecumbent patient position), during PLR and after returning to semirecumbent position. Simultaneously blood pressure (BP), pulse rate (PR), pulse oximetric saturation (SpO2) and ECG are recorded. The procedure is performed in ten normal subjects, ten patients recruited in the cardiology outpatient department and ten critically ill patients under analgosedation in the ICU.
Analysis includes changes in measured variables and heart rate variability in the frequency domain during the three phases of the experiment.
See above
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normal subjects | Active Comparator | Normal subjects 'Passive Leg Raising' |
|
| ICU patients | Active Comparator | ICU patients 'Passive Leg Raising' |
|
| Cardiac Outpatients | Active Comparator | Cardiac Outpatients 'Passive Leg Raising' |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Passive Leg Raising | Diagnostic Test | See above |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in cardiovascular variables I | stroke volume, SV (mL) | 10 minutes |
| Changes in cardiovascular variables II | pulse rate, PR (min^-1) | 10 minutes |
| Changes in cardiovascular variables III | blood pressure, BP (mmHg) | 10 minutes |
| Changes in cardiovascular variables IV | pulse oximetric saturation, SpO2 (%) | 10 minutes |
| Changes in HRV frequency domain variables V | Heart rate variability, HRV, variables in frequency domain (low frequency, LF, 0.04-0.15 Hz, high frequency, HF, 0.15-0.4 Hz) | 10 minutes |
| Changes in HRV frequency domain variables VI | HRV absolute power (ms^2, natural logarithm transformed values of absolute powers of very low frequency, VLF, LF, and HF bands) | 10 minutes |
| Changes in HRV frequency domain variables VII | HRV relative power (absolute power/total power) | 10 minutes |
| Changes in HRV frequency domain variables VIII | HRV normalized power (%, normalized units, n.u.) |
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Inclusion Criteria:
Consenting after written and oral information
Exclusion Criteria:
Contraindications to PLR: intracranial or abdominal hypertension
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| Name | Affiliation | Role |
|---|---|---|
| Peter Toft, MD | Head of Centre of Planned Surgery, Silkeborg Regional Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Regionshospitalet Silkeborg | Silkeborg | Central Jutland | 8600 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16540963 | Result | Monnet X, Rienzo M, Osman D, Anguel N, Richard C, Pinsky MR, Teboul JL. Passive leg raising predicts fluid responsiveness in the critically ill. Crit Care Med. 2006 May;34(5):1402-7. doi: 10.1097/01.CCM.0000215453.11735.06. |
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| 10 minutes |
| Changes in HRV frequency domain variables IX | HRV total power given by VLF + HF + LF (ms2) and LF/HF ratio. | 10 minutes |