Effect of Photodynamic Therapy on Gingival Crevicular Cytokines in Periodontitis Patients

Effect of Photodynamic Therapy on Gingival Crevicular Cytokines in Periodontitis Patients

Systemically healthy periodontitis patients were recruited in this single-blind, split-mouth, randomized controlled clinical trial. After SRP, PDT was applied at probing depth (PD) ≥ 4 mm at test quadrant. At baseline, 3rd month and 6th month, clinical parameters and cytokine pattern in gingival crevicular fluids (GCFs) were analysed.

Periodontal parameters and cytokine IL-1β, IL-6, IL-8, TNF-α, MMP-8 levels were analysed.

Inclusion Criteria:

• Adults who were medically fit or have medical condition that did not alter the outcome of periodontal treatment.
• Females who were not pregnant or nursing.
• Controlled diabetes mellitus with HbA1c < 7.5 mmol/L.
• Not on any antibiotics or steroids 3 months prior to periodontal treatment.
• Diagnosed to have either localized or generalized chronic or aggressive periodontitis (Armitage, 1999) with all 4 quadrants having at least 2 sites with probing depth ≥ 4 mm.
• Consented to follow the non-surgical periodontal treatment (scaling and root planing) with PDT throughout the period of study, i.e. approximately 6 months.

Exclusion Criteria:

• Allergic to photosensitizer or dye
• Pregnant lady and nursing mothers
• Uncontrolled diabetes