Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| National Heart, Lung, and Blood Institute (NHLBI) | NIH |
| Department of Health and Human Services | FED |
Not provided
Not provided
Not provided
Not provided
The investigators will conduct an epidemiological analysis of data from the Women's Health Initiative to investigate the prospective association between chocolate intake and the risk of heart disease and stroke.
BACKGROUND: Three recent meta-analyses found significant prospective inverse associations between chocolate intake and cardiovascular disease risk. Evidence from these meta-analyses suggests that such inverse associations may only apply to elderly individuals or those with preexisting major chronic disease.
OBJECTIVE: The investigators will assess the association between habitual chocolate intake and subsequent incident coronary heart disease (CHD) and stroke, and the potential effect of modification by age.
DESIGN: The investigators will conduct multivariable Cox regression analyses using data from 83,310 postmenopausal women free of baseline preexisting major chronic disease in the prospective Women's Health Initiative cohort. Chocolate intake was assessed using a food frequency questionnaire. Physician adjudicated events or deaths were ascertained up to September 30, 2013.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| chocolate consumption level referent | women who ate 1 oz. (28.35 g) of chocolate <1 time/month |
| |
| chocolate consumption level 2 | women who ate 1 oz. (28.35 g) of chocolate between 1 and <1.5 times/month |
| |
| chocolate consumption level 3 | women who ate 1 oz. (28.35 g) of chocolate between 1.5 and <3.5 times/month, |
| |
| chocolate consumption level 4 | women who ate 1 oz. (28.35 g) of chocolate between 3.5 times/month and <3 times/week |
| |
| chocolate consumption level 5 | women who ate 1 oz. (28.35 g) of chocolate >3 times/week |
| |
| No physician diagnosis | No incidence of serious chronic disease prior to visit 3 |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| chocolate consumption level | Behavioral | level of consumption of 1 oz. of chocolate, as assessed at baseline |
|
| Measure | Description | Time Frame |
|---|---|---|
| incidence of heart disease | physician adjudicated first occurrence of, or death due to, heart disease | between the baseline survey (1993-8) & September 30, 2013, average 13.4 years |
| incidence of stroke | physician adjudicated first occurrence of, or death due to, stroke | between the baseline survey (1993-8) & September 30, 2013, average 13.4 years |
| incidence of heart disease or stroke | physician adjudicated first occurrence of, or death due to, heart disease or stroke | between the baseline survey (1993-8) & September 30, 2013, average 13.4 years |
| change in chocolate intake | change in chocolate intake between visit 1 and 3 | time between the baseline and visit 3, average 3 years |
| change in dietary energy intake | change in dietary energy intake between visit 1 and 3 | time between the baseline and year 3, average 3 years |
| change in dietary fat intake | change in dietary fat intake between visit 1 and 3 | time between the baseline and year 3, average 3 years |
| change in BMI | change in BMI between visit 1 and 3 | time between the baseline and year 3, average 3 years |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
postmenopausal women 50-79 years of age
community residents
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29931040 | Result | Greenberg JA, Manson JE, Neuhouser ML, Tinker L, Eaton C, Johnson KC, Shikany JM. Chocolate intake and heart disease and stroke in the Women's Health Initiative: a prospective analysis. Am J Clin Nutr. 2018 Jul 1;108(1):41-48. doi: 10.1093/ajcn/nqy073. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
| D006331 | Heart Diseases |
| D020521 | Stroke |
| D003327 | Coronary Disease |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
|
| Physician diagnosis | Incidence of serious chronic disease prior to visit 3 |
|
| Younger | Age<65 years at follow-up baseline |
|
| Older | Age>=65 years at follow-up baseline |
|
| physician diagnosis of first occurrence of serious chronic disease | Other |
|
| D014652 | Vascular Diseases |
| D017202 | Myocardial Ischemia |