This study compares the neuroinflammatory response in patients with hypertensive ICH associated with IVH treated with intraventriculary applied rtPA, and the control group. The inflammatory mediator concentration is analyzed in local cerebrospinal liquor.

Inclusion Criteria:

• Subjects with primary ICH with IVH
• ICH score 2-4, , with origin of the hematoma in the basal ganglia and blood in the third and/or ventricle
• Patient is not considered a surgical candidate by neurosurgery service

Exclusion Criteria:

• No history of diseases or drugs that affect the immunological system.
• ICH score 1 and 5
• Current participation in another research drug treatment protocol
• Previously known intracranial arteriovenous malformation or aneurysms
• Intracerebral hematoma considered to be related to trauma
• ICH is located in the pons
• Blood in the subarachnoid space visualized on CT scan

All subjects from 18 to 80 years.