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| Name | Class |
|---|---|
| Uniformed Services University of the Health Sciences | FED |
| The Defense and Veterans Brain Injury Center | FED |
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Traumatic brain injury (TBI) is one of the most frequent injuries affecting service members. Unfortunately, current neurocognitive assessment tools are unable to reliably detect mild TBI more than a few days post- injury. Therefore, development of advanced systems for assessment and diagnosis of TBI are a top priority within Department of Defense. This project aims to evaluate a combined electroencephalography (EEG) and eye tracking system capable of assessing compromised cognitive function stemming from TBI, with the goal of enhancing operational readiness and aiding in diagnosis, improving health care and rehabilitation for affected military personnel.
This study (N=100) will be a correlational study to assess cognitive function in healthy controls, individuals with mild TBI, and individuals with moderate-to-severe TBI.
In general, participants will provide demographic information, medical history, and details of their head injury. Participants will also complete a brief neuropsychological assessment to obtain an index of cognitive ability, along with the Fusion Test with eye tracking and linked EEG. MRI data may also be obtained.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mild TBI Group | History of head injury, Active Duty Service Member or Veteran, age 18-55, fluent in English | ||
| Moderate to Severe TBI Group | History of head injury, Active Duty Service Member or Veteran, age 18-55, fluent in English | ||
| Healthy Controls | No history of head injury, Active Duty Service Member or Veteran, age 18-55, fluent in English |
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| Measure | Description | Time Frame |
|---|---|---|
| EEG | Spectral features and event related responses collected from scalp measurements during performance of an eye movement and working memory task. | One study visit |
| Eye Tracking | Saccadic latencies measured in response to cognitive task including working memory demands. | One study visit |
| Measure | Description | Time Frame |
|---|---|---|
| Neurobehavioral Symptom Inventory (NSI) | Self-report measure of post-concussive symptoms | One study visit |
| Trail Making Test | Consists of Part A and B which depends on psychomotor speed, visual search abilities, and placing demands on working memory and cognitive flexibility |
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Inclusion Criteria:
All groups:
Mild TBI group:
Moderate-to-Severe TBI group:
- History of moderate or severe TBI > 3 months and < 10 years prior to enrollment
Exclusion Criteria:
Control group:
History of possible or confirmed brain injury
All groups:
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Male and female service members with or without traumatic brain injury (TBI).
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Naval Medical Center San Diego | San Diego | California | 92134 | United States |
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| ID | Term |
|---|---|
| D000070642 | Brain Injuries, Traumatic |
| ID | Term |
|---|---|
| D001930 | Brain Injuries |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| One study visit |
| Symbol Search | Wechsler Adult Intelligence Scale- Fourth Edition (WAIS-IV) Symbol Search measures information processing speed | One study visit |
| Digit Span | WAIS-IV Digit Span including Digit Span Forward, Digit Span Backward, and Digit Span Sequencing, which measures memory span. | One study visit |
| D006259 |
| Craniocerebral Trauma |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |