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| Name | Class |
|---|---|
| Assiut University | OTHER |
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Hypertensive disorders of pregnancy are important cause of severe morbidity, long-term disability and death among both mothers and their babies. In Africa and Asia, nearly one tenth of all maternal deaths are associated with hypertensive disorders of pregnancy research has focused on the antenatal complications' for both mother and baby and the risks and benefits of administering antihypertensive therapy prior to delivery hypertension disorders of pregnancy often persist following delivery and sometimes arise de novo postpartum one of the maternal complications of pre eclampsia is residual chronic hypertension in about 1/3 of cases elevated blood pressure is seen in 6%to 8% of all pregnancies hypertension (arterial pressure >140/90 mmhg) in pregnancy is classified into one of four conditions
Hypertensive disorders of pregnancy are important cause of severe morbidity, long-term disability and death among both mothers and their babies. In Africa and Asia, nearly one tenth of all maternal deaths are associated with hypertensive disorders of pregnancy research has focused on the antenatal complications' for both mother and baby and the risks and benefits of administering antihypertensive therapy prior to delivery hypertension disorders of pregnancy often persist following delivery and sometimes arise de novo postpartum one of the maternal complications of pre eclampsia is residual chronic hypertension in about 1/3 of cases elevated blood pressure is seen in 6%to 8% of all pregnancies hypertension (arterial pressure >140/90 mmhg) in pregnancy is classified into one of four conditions
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| take oral nifedipine tablets | Active Comparator | Women who take the oral tablets of nifedipine till discharge of hospital |
|
| take oral labetalol tablets | Active Comparator | Women who take the oral tablets of labetalol till discharge of hospital |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oral Tablet | Drug | oral labetalol tablets and oral nifedipine tablets |
|
| Measure | Description | Time Frame |
|---|---|---|
| control blood pressure | duration,total dose to achieve blood pressure below the critical value between 140 and 150 mmHg systolic and 90-100 mmHg diastolic by monitoring of blood pressure | till discharge of hospital about two days |
| Measure | Description | Time Frame |
|---|---|---|
| Resolution of complications | Measured by monitoring of blood pressure and monitoring of the complications | till discharge of hospital about two days |
| Improvement of hematological values | By repeated Complete blood count |
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Inclusion Criteria:
Exclusion Criteria:
Women with history of secondary hypertension Women with eclampsia who need intensive care unit admission and indicated other drugs rather than oral nifedipine and oral labetalol Women who have any contraindication to Nifedipine or labetalol
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hossam Ahmed Abd Ellah, MBBCH | Contact | 0201119939775 | drhaaada@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Mohamed Mahmoud, Prof | Prof of ob& Gyn | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hossam Ahmed Abd Ellah | Recruiting | Asyut | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23741776 | Background | WHO Recommendations for Prevention and Treatment of Pre-Eclampsia and Eclampsia. Geneva: World Health Organization; 2011. Available from http://www.ncbi.nlm.nih.gov/books/NBK140561/ | |
| 17253478 | Background | Abalos E, Duley L, Steyn DW, Henderson-Smart DJ. Antihypertensive drug therapy for mild to moderate hypertension during pregnancy. Cochrane Database Syst Rev. 2007 Jan 24;(1):CD002252. doi: 10.1002/14651858.CD002252.pub2. |
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| ID | Term |
|---|---|
| D013607 | Tablets |
| D015924 | Blood Pressure Monitors |
| ID | Term |
|---|---|
| D004304 | Dosage Forms |
| D004364 | Pharmaceutical Preparations |
| D019722 | Sphygmomanometers |
| D019719 | Diagnostic Equipment |
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| till discharge of hospital about two days |
| Side effects in both groups | Monitoring if there is any side effect of any drug | till discharge of hospital about two days |
| Improvement of other investigations | Monitoring by repeated urine analysis,other investigations | till discharge of hospital about two days |
| 23633317 | Background | Magee L, von Dadelszen P. Prevention and treatment of postpartum hypertension. Cochrane Database Syst Rev. 2013 Apr 30;2013(4):CD004351. doi: 10.1002/14651858.CD004351.pub3. |
| Background | Geneva Foundation for Medical Education and Research 2017: hypertensive disorders in pregnancy |
| 8735301 | Background | ACOG technical bulletin. Hypertension in pregnancy. Number 219--January 1996 (replaces no. 91, February 1986). Committee on Technical Bulletins of the American College of Obstetricians and Gynecologists. Int J Gynaecol Obstet. 1996 May;53(2):175-83. No abstract available. |
| 11416689 | Background | Lenfant C; National Education Program Working Group on High Blood Pressure in Pregnancy. Working group report on high blood pressure in pregnancy. J Clin Hypertens (Greenwich). 2001 Mar-Apr;3(2):75-88. doi: 10.1111/j.1524-6175.2001.00458.x. |
| D004864 |
| Equipment and Supplies |