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In this study, the investigators examine whether emotional and social reward from alcohol varies depending on the social context of consumption.
Objective: Although the vast majority of alcohol consumption outside the laboratory occurs in social context, experimental studies of alcohol's emotionally reinforcing effects have overwhelmingly examined individuals drinking in isolation. The current study examines motivationally salient elements of everyday social drinking contexts as moderators of alcohol-related reinforcement. More specifically, the present study examine whether alcohol is more reinforcing within the context of unfamiliar vs. familiar social interaction and, further, whether alcohol is more reinforcing within the context of low vs. high quality social relationships. The current study furthermore examine whether individuals with characteristics that put them at risk for developing an alcohol use disorder (e.g., male gender, impulsive/extraverted personality profile, heavy patterns of consumption, family history of AUD, ...) exhibit heightened emotional reinforcement from alcohol within these social drinking contexts.
The current project represents a test of competing theories of alcohol reinforcement. Alcohol myopia theory-which has heretofore represented the most prominent theory of alcohol's effects-predicts that alcohol's ability to relieve stress depends on the nature (positive or negative) of stimuli in the drinker's immediate environment. Alcohol myopia theory might thus predict that alcohol's rewarding effects will be larger within familiar interactions and within secure relationships. In contrast, the social attributional theory of alcohol reinforcement predicts that alcohol-related reinforcement will be most pronounced within the context of unfamiliar social interactions.
In addition to providing an opportunity to test contextual and individual-level moderators of alcohol reinforcement, the current study represents an opportunity to directly test the replicability of research indicating a pronounced reinforcing effect of alcohol specifically within interactions among unfamiliar individuals (Sayette et al., 2012; Fairbairn et al., 2013).
Study Population: Participants will consist of 640 male and female drinkers, aged 21-30, with no reported history of severe alcohol use disorder. Participants will be sampled such that at least 360 of these participants will classify as heavy drinkers.
Design: In the laboratory arm of the study, individuals will be randomly assigned to consume either a moderate dose of alcohol or a control beverage in the company of either familiar or unfamiliar individuals. Of these individuals, a subset will participate in additional tasks post beverage-consumption including a hyperscanning EEG task, while an additional subset will also participate in an ambulatory assessment period over the course of several weeks to examine the interaction of alcohol and social contextual factors in daily life. In the ambulatory study arm, participants will wear transdermal sensors to assess BAC and will further provide information about their mood and their social contexts in response to random prompts.
Outcome Measures: Primary outcome measures include self-reports of positive and negative mood and perceived social reinforcement. The investigators will also examine facial expressions using the Facial Action Coding System, a comprehensive, anatomically-based system for categorizing facial muscle movement. One aim of the current study is to examine whether differential reinforcement from alcohol in unfamiliar social contexts emerges only with respect to self-reports, or is also observable within facial behaviors. EEG/ERP measures will also be examined for a subset of participants engaged in a hyperscanning task.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Alcohol Administration | Experimental | A moderate dose of alcohol (Target BAC .08%) |
|
| Control Beverage Administration | No Intervention | Participants consume a non-alcoholic beverage |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Alcohol | Drug | Alcohol Target BAC .08% |
|
| Measure | Description | Time Frame |
|---|---|---|
| Self-Reported Emotion | Positive and negative emotion will be assessed during the laboratory beverage-administration session via self-report on the "8-item Mood Measure." This measure yields two subscales (positive emotion; negative emotion) each ranges from 1 to 6. For positive mood, higher value represents increased alcohol reward. For negative mood, lower value represents increased alcohol reward. | during the laboratory session, up to 9 hours |
| Self-Reported Social Reinforcement | Social reinforcement will be assessed using an index of perceived social closeness as well as a modified version of the Perceived Group Reinforcement Scale. The score of the scale ranges from 1 to 9. Higher score indicates increased alcohol reward. | during the laboratory session, up to 9 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Social Bonding | Social bonding will be assessed during the laboratory beverage-administration session. This will be assessed by examining the synchronization among group members of facial expressions of emotion. | 1 day (laboratory session) |
| Self-Reported Emotion |
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Inclusion Criteria:
Exclusion Criteria:
May be either male or female, but must be same as gender assigned at birth.
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| Name | Affiliation | Role |
|---|---|---|
| Catharine E Fairbairn, Ph.D. | University of Illinois at Urbana-Champaign | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Illinois at Urbana-Champaign | Champaign | Illinois | 61820 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 2221564 | Background | Steele CM, Josephs RA. Alcohol myopia. Its prized and dangerous effects. Am Psychol. 1990 Aug;45(8):921-33. doi: 10.1037//0003-066x.45.8.921. | |
| 28287750 | Background | Fairbairn CE. Drinking among strangers: A meta-analysis examining familiarity as a moderator of alcohol's rewarding effects. Psychol Addict Behav. 2017 May;31(3):255-264. doi: 10.1037/adb0000264. Epub 2017 Mar 13. |
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| ID | Title | Description |
|---|---|---|
| FG000 | Alcohol Administration | Primary participants in the current study consisted of both eligible individuals who first contacted the lab and their eligible friends. Here we report the total number of individual participants (both initial contacts and their friends) who received a moderate dose of alcohol (Target BAC .08%). |
| FG001 | Control Beverage Administration | Primary participants in the current study consisted of both eligible individuals who first contacted the lab and their eligible friends. Here we report the total number of individual participants (both initial contacts and their friends) who received a non-alcoholic beverage. |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
Primary participants in the current study consisted of both eligible individuals who first contacted the lab and their eligible friends. Here we report the total number of individual participants (both initial contacts and their friends) enrolled in the study.
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| ID | Title | Description |
|---|---|---|
| BG000 | Alcohol Administration | Primary participants in the current study consisted of both eligible individuals who first contacted the lab and their eligible friends. Here we report the data from individual participants (both initial contacts and their friends) who received a moderate dose of alcohol (Target BAC .08%). |
| BG001 |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Self-Reported Emotion | Positive and negative emotion will be assessed during the laboratory beverage-administration session via self-report on the "8-item Mood Measure." This measure yields two subscales (positive emotion; negative emotion) each ranges from 1 to 6. For positive mood, higher value represents increased alcohol reward. For negative mood, lower value represents increased alcohol reward. | Posted | Mean | Standard Deviation | score on a scale | during the laboratory session, up to 9 hours |
|
6-9 hours (length of the laboratory session)
The intervention of the study is laboratory alcohol administration.
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Alcohol Administration | Primary participants in the current study consisted of both eligible individuals who first contacted the lab and their eligible friends. Here we report the number of individual participants (both initial contacts and their friends) who received a moderate dose of alcohol (Target BAC .08%). |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Dr. Catharine Fairbairn | University of Illinois at Urbana-Champaign | 215-300-5850 | cfairbai@illinois.edu |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Apr 23, 2024 | Apr 24, 2024 | Prot_SAP_001.pdf |
| ICF | No | No | Yes | Informed Consent Form | Feb 22, 2022 | Jun 21, 2022 | ICF_000.pdf |
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| ID | Term |
|---|---|
| D000428 | Alcohol Drinking |
| D000437 | Alcoholism |
| D000435 | Alcoholic Intoxication |
| D063425 | Binge Drinking |
| ID | Term |
|---|---|
| D004327 | Drinking Behavior |
| D001519 | Behavior |
| D019973 | Alcohol-Related Disorders |
| D019966 | Substance-Related Disorders |
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| ID | Term |
|---|---|
| D000431 | Ethanol |
| ID | Term |
|---|---|
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
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Positive and negative emotion will be assessed during the ambulatory assessment period via self-report on the "8-item Mood Measure." |
| 2-3 week ambulatory assessment period |
| Interpersonal Distance | Physical proximity to other participants during the experiment | 1 day (laboratory session) |
| Neuro-cognitive Social Engagement | Electroencephalogram (EEG) hyperscanning methods will be employed to assess task engagement and social attention, including through the examination of event-related potentials (ERPs) during social tasks. | 1 day (laboratory session) |
| 25180806 | Background | Fairbairn CE, Sayette MA. A social-attributional analysis of alcohol response. Psychol Bull. 2014 Sep;140(5):1361-82. doi: 10.1037/a0037563. |
| 22760882 | Background | Sayette MA, Creswell KG, Dimoff JD, Fairbairn CE, Cohn JF, Heckman BW, Kirchner TR, Levine JM, Moreland RL. Alcohol and group formation: a multimodal investigation of the effects of alcohol on emotion and social bonding. Psychol Sci. 2012 Aug 1;23(8):869-78. doi: 10.1177/0956797611435134. Epub 2012 Jul 3. |
| 24016015 | Background | Fairbairn CE, Sayette MA. The effect of alcohol on emotional inertia: a test of alcohol myopia. J Abnorm Psychol. 2013 Aug;122(3):770-81. doi: 10.1037/a0032980. |
| Control Beverage Administration |
Primary participants in the current study consisted of both eligible individuals who first contacted the lab and their eligible friends. Here we report the data from individual participants (both initial contacts and their friends) who received a non-alcoholic beverage. |
| BG002 | Total | Total of all reporting groups |
| years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Ethnicity (NIH/OMB) | Count of Participants | Participants |
|
| Race (NIH/OMB) | Count of Participants | Participants |
|
| Region of Enrollment | Number | participants |
|
| Education level | Mean | Standard Deviation | Years of Education |
|
| Control Beverage Administration |
Primary participants in the current study consisted of both eligible individuals who first contacted the lab and their eligible friends. Here we report the data from individual participants (both initial contacts and their friends) who received a non-alcoholic beverage. |
|
|
|
| Primary | Self-Reported Social Reinforcement | Social reinforcement will be assessed using an index of perceived social closeness as well as a modified version of the Perceived Group Reinforcement Scale. The score of the scale ranges from 1 to 9. Higher score indicates increased alcohol reward. | Posted | Mean | Standard Deviation | score on a scale | during the laboratory session, up to 9 hours |
|
|
|
|
| Secondary | Social Bonding | Social bonding will be assessed during the laboratory beverage-administration session. This will be assessed by examining the synchronization among group members of facial expressions of emotion. | Not Posted | 1 day (laboratory session) | Participants |
| Secondary | Self-Reported Emotion | Positive and negative emotion will be assessed during the ambulatory assessment period via self-report on the "8-item Mood Measure." | Not Posted | 2-3 week ambulatory assessment period | Participants |
| Secondary | Interpersonal Distance | Physical proximity to other participants during the experiment | Not Posted | 1 day (laboratory session) | Participants |
| Secondary | Neuro-cognitive Social Engagement | Electroencephalogram (EEG) hyperscanning methods will be employed to assess task engagement and social attention, including through the examination of event-related potentials (ERPs) during social tasks. | Not Posted | 1 day (laboratory session) | Participants |
| 0 |
| 320 |
| 0 |
| 320 |
| 0 |
| 320 |
| EG001 | Control Beverage Administration | Primary participants in the current study consisted of both eligible individuals who first contacted the lab and their eligible friends. Here we report the number of individual participants (both initial contacts and their friends) who received a non-alcoholic beverage. | 0 | 320 | 0 | 320 | 0 | 320 |
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| D064419 |
| Chemically-Induced Disorders |
| D001523 | Mental Disorders |