Efficacy of Mydriatic Drops in Premature Infants

Efficiency and Safety of Phenylephrine and Tropicamide Used in Premature Retinopathy

Because of the neonatologists reported that some infants had suffered from vomiting, bradycardia, hypotonia, and aspiration risk about 30-60 minutes after the fundus examination in the intensive care unit. The investigators observed the pupil dilation effects and side effects of tipple instillation of phenylephrine 2.5% plus tropicamide 0.5% ophthalmic drop combination which the investigators routinely used in ROP examination.

Purpose: To determine effect and vital change after topical application of phenylephrine 2.5% and tropicamide 0.5% three times for retinopathy of prematurity (ROP) examination in preterm infants.

Methods: Pupillary diameter, blood pressure, pulse rate, and oxygen saturation were monitored before, and after up to 24 hours 60 ROP screening examinations.

Inclusion Criteria:

• Infants who were first ROP examinations
• infants born before 32 weeks.

Exclusion Criteria:

• Developmental ocular and/or systemic anomalies.
• Drug use that can affect vital values
• Unstable general condition
• Food intolerance
• Recurrent vomiting.