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Autoimmune thyroiditis (AITD) mainly includes Hashimoto's thyroiditis (HT) and Grave's disease (GD). Studies have shown that autoimmune thyroiditis is closely related to microbial disorders such as autoimmune thyroiditis However, there is no report on the relationship between oral microecology and autoimmune thyroiditis. Therefore, our group will study the correlation between oral microbiota and AITD.
Autoimmune thyroiditis (AITD) mainly includes Hashimoto's thyroiditis (HT) and Grave's disease (GD). Studies have shown that autoimmune thyroiditis is closely related to microbiological disorders. Intestinal microelements Both ecology and oral microecology belong to the category of microorganisms. It has been reported in the literature that intestinal microecology occurs disorder of autoimmune thyroiditis. However, there is no report on the correlation between oral microecology and autoimmune thyroiditis. When oral microbe flora When the immune system is disrupted, the immune balance is broken, the immune system is over-active, and the autoimmune disease (AID) is lost to the autoantigens and non-pathogenic commensal microbial flora antigens, including rheumatoid arthritis, Sjogren's syndrome, systemic lupus erythematosus, inflammatory bowel disease, and allergic diseases. However, the association between oral microbial flora and AITD remains unclear. . Therefore, the research group will carry out the correlation between oral microbial flora and AITD.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control group | 30 healthy volunteers were included in the healthy control group | ||
| Drug treatment group | 30 GD patients who received treatment with Methimazole Pill or propylthiouracil pill |
| |
| Incipient group | 30 untreated GD patients | ||
| Hashimoto's thyroiditis group | 30 HT patients |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Methimazole Pill | Drug | Patients who developed GD received methimazole treatment |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Transcriptional changes in oral microbiota | The microbiota measured by 16S rRNA gene | Baseline, 3 months, 6 months, 9 months, 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Serum thyroid function changed | Serum thyroid function measured by Immunohistochemistry | Baseline, 3 months, 6 months, 9 months, 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Serum thyroid related antibodies changed | Serum thyroid related antibodies measured by Immunohistochemistry | Baseline, 3 months, 6 months, 9 months, 12 months |
Inclusion Criteria:
Exclusion Criteria:
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All patients were included according to the inclusion and exclusion criteria
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yunwei Wei | Contact | +86-0451-85553099 | hydwyw11@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Yunwei Wei | First Affiliated Hospital of Harbin Medical University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| First affiliated hospital of Harbin medical university | Recruiting | Harbin | Heilongjiang | 150001 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20203603 | Background | Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, Manichanh C, Nielsen T, Pons N, Levenez F, Yamada T, Mende DR, Li J, Xu J, Li S, Li D, Cao J, Wang B, Liang H, Zheng H, Xie Y, Tap J, Lepage P, Bertalan M, Batto JM, Hansen T, Le Paslier D, Linneberg A, Nielsen HB, Pelletier E, Renault P, Sicheritz-Ponten T, Turner K, Zhu H, Yu C, Li S, Jian M, Zhou Y, Li Y, Zhang X, Li S, Qin N, Yang H, Wang J, Brunak S, Dore J, Guarner F, Kristiansen K, Pedersen O, Parkhill J, Weissenbach J; MetaHIT Consortium; Bork P, Ehrlich SD, Wang J. A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 2010 Mar 4;464(7285):59-65. doi: 10.1038/nature08821. | |
| 20656903 |
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| ID | Term |
|---|---|
| D006111 | Graves Disease |
| D050031 | Hashimoto Disease |
| ID | Term |
|---|---|
| D005094 | Exophthalmos |
| D009916 | Orbital Diseases |
| D005128 | Eye Diseases |
| D006042 | Goiter |
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| ID | Term |
|---|---|
| D008713 | Methimazole |
| D011441 | Propylthiouracil |
| ID | Term |
|---|---|
| D013438 | Sulfhydryl Compounds |
| D013457 | Sulfur Compounds |
| D009930 | Organic Chemicals |
| D007093 | Imidazoles |
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| Propylthiouracil Pill |
| Drug |
Patients who developed GD received propylthiouracil treatment |
|
| Background |
| Dewhirst FE, Chen T, Izard J, Paster BJ, Tanner AC, Yu WH, Lakshmanan A, Wade WG. The human oral microbiome. J Bacteriol. 2010 Oct;192(19):5002-17. doi: 10.1128/JB.00542-10. Epub 2010 Jul 23. |
| 25729852 | Background | Kabouridis PS, Pachnis V. Emerging roles of gut microbiota and the immune system in the development of the enteric nervous system. J Clin Invest. 2015 Mar 2;125(3):956-64. doi: 10.1172/JCI76308. Epub 2015 Mar 2. |
| D013959 |
| Thyroid Diseases |
| D004700 | Endocrine System Diseases |
| D006980 | Hyperthyroidism |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D013967 | Thyroiditis, Autoimmune |
| D013966 | Thyroiditis |
| D001393 |
| Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D013889 | Thiouracil |
| D014498 | Uracil |
| D011744 | Pyrimidinones |
| D011743 | Pyrimidines |