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This study is attempting to improve word finding and memory retrieval problems persons with mild cognitive impairment (MCI) may have.
This study attempts to improve word finding and memory retrieval problems in persons with mild cognitive impairment (MCI). To remember and find words, the brain has to search for the correct memory and MCI can negatively affect this search. Studies have suggested that low level electrical stimulation of the memory retrieval circuit can improve memory recall. The purpose of this study is to find the exact influence of multi-electrode or High Definition transcranial Direct Current Stimulation (HD-tDCS) by targeting a frontal and a parietal brain area, and their roles in memory retrieval/word finding in MCI. By modulating ongoing activity in 6 sessions of HD-tDCS the study investigates whether HD-tDCS may be used as a way to improve memory retrieval/word finding evaluated by cognitive measures and electroencephalography (EEG) measures before the first session and after the last session of HD-tDCS with a follow-up session 1-month after the stimulation procedure.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Active frontal | Experimental | Active HD-tDCS |
|
| Active parietal | Experimental | Active HD-tDCS |
|
| Sham control | Sham Comparator | Sham HD-tDCS |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Active frontal | Device | 1) active HD-tDCS will be administered |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Memory retrieval/word finding assessment. | Changes in cognitive performance are compared between the 3 groups to investigate the influence of HD-tDCS on memory retrieval/word finding. | Baseline (before the first HD-tDCS session), immediate post (immediately after the last HD-tDCS session) and 1 month follow up (1 month after the last HD-tDCS session) |
| Measure | Description | Time Frame |
|---|---|---|
| Electroencephalography (EEG). | Brain activity is recorded with electroencephalography (EEG) and is compared between the 3 groups to investigate the influence of HD-tDCS on memory retrieval/word finding. | Baseline (before the first HD-tDCS session), immediate post (immediately after the last HD-tDCS session) and 1 month follow up (1 month after the last HD-tDCS session) |
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Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sven Vanneste, PhD | The University of Texas at Dallas | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Texas at Dallas | Richardson | Texas | 78080 | United States |
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| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
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| Active parietal |
| Device |
2) active HD-tDCS will be administered |
|
| Sham | Device | 3) sham HD-tDCS - no current |
|