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| Name | Class |
|---|---|
| Favaloro Foundation University Hospital, Buenos Aires, Argentina | UNKNOWN |
| MedStar Georgetown University Hospital | OTHER |
| Hospital Universitario La Paz | OTHER |
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The study validates prospectively a new endoscopic scoring system (Gothenburg Intestinal Transplant Endoscopy Score, GITES) designed to summarize and stratify the abnormal ileal endoscopic findings after intestinal transplantation. GITES is a five-tier, four grade score which asseses mucosal friability, mucosal erythema and mucosal injury (ulcerations) as well as villous changes according to severity. These features (i.e., endoscopic descriptors) are also grouped from mild to very severe in the same sequence as observed during the progression of several pathologic conditions encountered after intestinal transplantation (acute rejection, infectious enteritis).
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| Measure | Description | Time Frame |
|---|---|---|
| Endoscopic evaluation | To validate the GITES grading system in intestinal graft recipients using high-definition white light endoscopy | 7 years |
| Measure | Description | Time Frame |
|---|---|---|
| Correlations with histology and Clinical course | Comparison and correlation of clinical and histopathological data with endoscopic findings to evaluate the conditions leading to the mucosal alterations defined by established endoscopic descriptors and GITES. | 1 year |
| Performance of the grading score |
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Inclusion Criteria:
Exclusion Criteria:
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All patients (pediatric or adult) undergoing intestinal transplantation (isolated intestine, liver-intestine, multivisceral, including colon or other organs) irrespective of diagnosis; patients already transplanted can also be included.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mihai Oltean, M.D., Ph.D. | Contact | 00 46 31 342 1000 | mihai.oltean@surgery.gu.se |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| MedStar Georgetown University Hospital | Recruiting | Washington D.C. | District of Columbia | 20007 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 9468243 | Background | Sigurdsson L, Reyes J, Putnam PE, del Rosario JF, Di Lorenzo C, Orenstein SR, Todo S, Kocoshis SA. Endoscopies in pediatric small intestinal transplant recipients: five years experience. Am J Gastroenterol. 1998 Feb;93(2):207-11. doi: 10.1111/j.1572-0241.1998.00207.x. | |
| 8908053 | Background | Tabasco-Minguillan J, Weber K, Nelson F, Hutson W, Furukawa H, Abu-Elmagd K, Todo S, Rakela J. Variability in the interpretations of endoscopic findings in patients with intestinal transplantation. Transplant Proc. 1996 Oct;28(5):2775-6. No abstract available. |
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| ID | Term |
|---|---|
| D012059 | Rejection, Psychology |
| D004751 | Enteritis |
| D052016 | Mucositis |
| ID | Term |
|---|---|
| D012919 | Social Behavior |
| D001519 | Behavior |
| D005759 | Gastroenteritis |
| D005767 | Gastrointestinal Diseases |
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Endpoints include sensitivity, specificity, positive predictive value, negative predictive value as well as inter- and intraobserver variation in the evaluation of the mucosal alterations by means of GITES and using high-definition white light endoscopy; |
| 1 year |
| Favaloro Foundation University Hospital | Recruiting | Buenos Aires | C1093AAS | Argentina |
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| Hospital Universitario "La Paz" | Recruiting | Madrid | Spain |
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| Sahlgrenska University Hospital | Recruiting | Gothenburg | 41345 | Sweden |
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| 29233031 | Background | Varkey J, Stotzer PO, Simren M, Herlenius G, Oltean M. The endoscopic surveillance of the transplanted small intestine: a single center experience and a proposal for a grading score. Scand J Gastroenterol. 2018 Feb;53(2):134-139. doi: 10.1080/00365521.2017.1411523. Epub 2017 Dec 12. |
| D004066 |
| Digestive System Diseases |
| D007410 | Intestinal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |