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| Name | Class |
|---|---|
| Brigham and Women's Hospital | OTHER |
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The objective of CAREBANK study is to establish definitive relationships with human cardiac samples and clinical phenotypes in patients undergoing cardiac procedures. Specifically, the investigators aim at comparing atrial phenotypes from atrial fibrillation patients and controls. The work consists of three broad categories: A) role of atrial cardiomyopathy in atrial fibrillation; B) genetic defects predisposing to atrial fibrillation; and C) the role of inflammation in atrial fibrillation.
The investigators aim to A) compare atrial cardiomyopathy findings from the tissue samples to clinical phenotype and adverse events B) study the association of genetic defects predisposing to atrial fibrillation with atrial cardiomyopathy findings in the tissue samples C) assess the role of inflammation in atrial fibrillation by comparing circulating cytokine profiles, purinergic signaling and atrial cardiomyopathy findings in tissue samples.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Atrial fibrillation | Patients with atrial fibrillation |
| |
| Coronary bypass | Patients undergoing coronary bypass |
| |
| Aortic valve replacement | Patients undergoing aortic valve replacement |
| |
| Mitral valve repair | Patients undergoing mitral valve repair |
| |
| Other | Patients undergoing cardiac surgery for indication other than above |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cardiac surgery | Procedure | Open heart surgery |
|
| Measure | Description | Time Frame |
|---|---|---|
| Atrial fibrillation | Occurrence of atrial fibrillation | postoperatively until 5 years follow-up |
| Measure | Description | Time Frame |
|---|---|---|
| Stroke | Occurrence of stroke | postoperatively until 5 years follow-up |
| Transient ischemic attack | Occurrence of Transient ischemic attack |
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Inclusion Criteria:
Exclusion Criteria:
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Consecutive patients undergoing open-heart cardiac surgery
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| Name | Affiliation | Role |
|---|---|---|
| Tuomas O Kiviniemi, MD, PhD | Turku University Hospital | Study Director |
| Jarmo Gunn, MD, PhD | Turku University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Turku University Hospital | Turku | 20520 | Finland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41840772 | Derived | Viikinkoski E, Lehto J, Relander A, Jalkanen J, Gunn J, Vasankari T, Biancari F, Airaksinen JKE, Hollmen M, Kiviniemi TO. Prolonged Systemic Inflammatory Response Syndrome Predicts Atrial Fibrillation After Cardiac Surgery. Interdiscip Cardiovasc Thorac Surg. 2026 Mar 12;41(3):ivag081. doi: 10.1093/icvts/ivag081. | |
| 39091640 | Derived |
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Atrial appendage, valves, ascending aorta, pericardium
| postoperatively until 5 years follow-up |
| Myocardial infarction | Occurrence of Myocardial infarction | postoperatively until 5 years follow-up |
| Target vessel revascularization | Occurrence of Target vessel revascularization | postoperatively until 5 years follow-up |
| All-cause Mortality | All-cause Mortality | postoperatively until 5 years follow-up |
| Post-pericardiotomy syndrome | Occurrence of Post-pericardiotomy syndrome | postoperatively until 1 years follow-up |
| Maaniitty E, Sinisilta S, Jalkanen J, Vasankari T, Biancari F, Gunn J, Jalkanen S, Airaksinen KEJ, Hollmen M, Kiviniemi T. Distinct circulating cytokine levels in patients with angiography-proven coronary artery disease compared to disease-free controls. Int J Cardiol Cardiovasc Risk Prev. 2024 Jul 4;22:200307. doi: 10.1016/j.ijcrp.2024.200307. eCollection 2024 Sep. |
| 39068298 | Derived | Maaniitty E, Jalkanen J, Sinisilta S, Gunn J, Vasankari T, Biancari F, Jalkanen S, Airaksinen KEJ, Hollmen M, Kiviniemi T. Differential circulating cytokine profiles in acute coronary syndrome versus stable coronary artery disease. Sci Rep. 2024 Jul 27;14(1):17269. doi: 10.1038/s41598-024-68333-7. |
| 34782683 | Derived | Viikinkoski E, Jalkanen J, Gunn J, Vasankari T, Lehto J, Valtonen M, Biancari F, Jalkanen S, Airaksinen KEJ, Hollmen M, Kiviniemi TO. Red blood cell transfusion induces abnormal HIF-1alpha response to cytokine storm after adult cardiac surgery. Sci Rep. 2021 Nov 15;11(1):22230. doi: 10.1038/s41598-021-01695-4. |
| ID | Term |
|---|---|
| D001281 | Atrial Fibrillation |
| D003324 | Coronary Artery Disease |
| D001024 | Aortic Valve Stenosis |
| D000082862 | Aortic Valve Disease |
| D006338 | Heart Neoplasms |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D006349 | Heart Valve Diseases |
| D014694 | Ventricular Outflow Obstruction |
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| D006348 | Cardiac Surgical Procedures |
| ID | Term |
|---|---|
| D013504 | Cardiovascular Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
| D019616 | Thoracic Surgical Procedures |
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