Impact of Short-term Fructose-enriched Diet on Serum Metabolome by Normal- and Over-weighed Women.

Impact of Short-term Fructose-enriched Diet on Serum Metabolome by Normal- and Over-weighed Women.

The purpose of this study is to investigate how a high-fructose diet, either by high fructose intake from complex, natural foods or by fortifying the diet with corn syrup, affects the metabolism. Furthermore, it will be investigate if there are differences between obese and normal weight participants.

Inclusion Criteria:

• Healthy adults, aged between 20 and 30 years
• normal weighted (BMI ≤ 25 kg/m2) and obese (BMI 35-50 kg/m2)
• written informed consent

At initial medical examination an anamnesis, physical examination, blood sample collection (10 ml) was performed to check for eligibility. Furthermore, a hydrogen breath test was performed to detect potential fructose intolerance

Exclusion Criteria:

• smoking,
• fructose intolerance/ -malabsorption,
• pregnancy
• chronic gastrointestinal diseases (e.g. chronic inflammatory bowel disease, irritable bowel syndrome, celiac disease etc.),
• operation on the gastrointestinal tract (exclusively appendectomy)
• anemia,
• hepatic or renal disease
• diabetes mellitus
• consuming illnesses (e.g. cancer, acquired immunodeficiency syndrome (AIDS)) - drug intake affecting lipid or glucose metabolism (cholesterol- or glucose reducing or antihypertensive drugs, steroids, L-Thyroxin, antidepressants, weight reducing drugs).