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The research project includes two components that assess exercise physiology parameters, cerebrovascular reserve, cognitive functions and cardiac function in coronary heart disease patients at rest, during an acute exercise, and after two different periodized training programs.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Linear training | Experimental | Linear training consists to a progressive improvement of the training load during the 3 month-program. |
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| Non-linear training | Experimental | Non-linear training consists to an undulating progressive improvement of the training load during the 3 month-program. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise training | Other | Patients will undergo three weekly exercise training sessions with periodized high-intensity interval training and resistance training for a period of 12 weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| Maximal oxygen uptake (VO2peak) with gas exchange | VO2peak will be measured during maximal exercise test with a gas exchange device. The highest value reached during the exercise phase of the maximal test (ergocycle) will be considered as the VO2peak. We will measure change of VO2peak before and after exercise training. | At baseline and following 12 weeks exercise training intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Cerebral hemodynamics | Cerebral hemodynamics will be measured using near-infrared spectroscopy (NIRS) system during maximal and submaximal exercise tests. We will measure change of cerebral hemodynamics before and after exercise training | At baseline and following 12 weeks exercise training intervention |
| Cognitive functions at rest by a by standard pen-paper battery test |
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Inclusion Criteria for patients with coronary heart disease:
Exclusion Criteria for patients with coronary heart disease:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cardiovascular prevention and rehabilitation center | Montreal | Quebec | H1T 1N6 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41739167 | Derived | Gayda M, Trachsel LD, Besnier F, Boidin M, Lalonge J, Bherer L, Juneau M, Lepretre PM, Nigam A. Effects of different exercise training programs on post-exercise [Formula: see text]O2 recovery responses in patients with coronary heart disease. Eur J Appl Physiol. 2026 Feb 25. doi: 10.1007/s00421-026-06146-4. Online ahead of print. | |
| 33108743 |
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| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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Cognitive functions will be measured at rest with a pen-paper battery test by a neuropsychologist. We will measure change of score to the cognitive tests before and after exercise training. |
| At baseline and following 12 weeks exercise training intervention |
| Cardiac hemodynamics | Cardiac hemodynamics will be measured continuously during the maximal exercise test on bike using an impedance cardiography device. We will measure change of cardiac hemodynamics before and after exercise training. | At baseline and following 12 weeks exercise training intervention |
| Standard echocardiographic parameter of left and right ventricular strain | global longitudinal strain (%) will be measued at rest for both ventricule | At baseline and following 12 weeks exercise training intervention |
| Boidin M, David LP, Trachsel LD, Gayda M, Tremblay J, Lalonge J, Juneau M, Nigam A, Henri C. Impact of 2 different aerobic periodization training protocols on left ventricular function in patients with stable coronary artery disease: an exploratory study. Appl Physiol Nutr Metab. 2021 May;46(5):436-442. doi: 10.1139/apnm-2020-0423. Epub 2020 Oct 27. |
| 33096006 | Derived | Trachsel LD, Boidin M, Henri C, Fortier A, Lalonge J, Juneau M, Nigam A, Gayda M. Women and men with coronary heart disease respond similarly to different aerobic exercise training modalities: a pooled analysis of prospective randomized trials. Appl Physiol Nutr Metab. 2021 May;46(5):417-425. doi: 10.1139/apnm-2020-0650. Epub 2020 Oct 23. |