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SARS-CoV has caused severe epidemic respiratory disease in human populations. By July 2003, a total of 8,096 probable cases of SARS had been reported including 774 deaths in 27 countries, around one-third of which were health care workers (HCWs). Previous studies have been reported about long-term impacts of SARS infection, including lung function deficiency, steroid-induced osteonecrosis, reduced exercise capacity, and impairment in health-related quality of life (HRQoL). HCWs, especially nurses, have been reported to experience greater psychological distress, particularly increased levels of posttraumatic stress symptomatology (PTSS). But the very complex impacts of this fatal infection on HCWs have not been fully elucidated. It is thus important to follow these occupational patients to detect and manage multi-organ sequelae and functional impairment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| SARS survivors | First-line HCWs infected during the SRAS-CoV pandemic in Peking University People's Hospital, China. Diagnose was further confirmed by SARS-CoV seropositive results. | ||
| Controls |
|
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| Measure | Description | Time Frame |
|---|---|---|
| All-cause disability | Disabilities arising from physical injuries and/or mental stresses | Evaluations would be finished within 90 days after enrollment. |
| Measure | Description | Time Frame |
|---|---|---|
| Cardiopulmonary function | The interrelationship between the workings of the heart and lung organs would be assessed by assessed by 6MWT (6-min walk test) | Evaluations would be finished within 90 days after enrollment. |
| Life Life quaities mental distress |
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Inclusion Criteria:
Exclusion Criteria:
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Health care workers who were working at Peking University People's Hospital during the SARS epidemic in 2002-2003 will be enrolled.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yali Zheng, Dr | Contact | +8615011451515 | yali_zheng@126.com | |
| Jia Li, Dr | Contact | +8613661310120 | lj10120@sina.com |
| Name | Affiliation | Role |
|---|---|---|
| Baoguo Jiang, Dr | Peking University People's Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Peking University People's Hospital | Recruiting | Beijing | Beijing Municipality | 100044 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34819019 | Derived | Li J, Zheng Y, Zhao L, Yue Z, Pan F, Chen Y, Yu B, Chen Y, Zhao G, Zhou Y, Gao Z. Investigation of the impact of SARS-CoV infection on the immunologic status and lung function after 15 years. BMC Infect Dis. 2021 Nov 24;21(1):1183. doi: 10.1186/s12879-021-06881-3. |
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| ID | Term |
|---|---|
| D045169 | Severe Acute Respiratory Syndrome |
| ID | Term |
|---|---|
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
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Peripheral Blood Mononuclear Cells would be extracted from participators.
Quality of life would be assessed by the Medical Outcomes Study 36-item short form version 2 (SF-36) |
| Evaluations would be finished within 90 days after enrollment. |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D012140 | Respiratory Tract Diseases |