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The purpose of this study is to determine what type of reactions in the body may be responsible for the respiratory symptoms that occur when patients with Aspirin Exacerbated Respiratory Disease (AERD) drink alcoholic beverages. These reactions are most often seen with red wine.
This is a prospective trial of approximately 60 subjects with AERD to explore the mechanisms behind the physiologic reactions that occur when drinking alcoholic beverages. At various time points patients will be asked to ingest a variety of substances found in red wine after which blood and urine markers of the reaction will be measured.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Active Comparator | Patients without asthma or aspirin intolerance who may or may not react to alcoholic beverages |
|
| Aspirin Tolerant Asthma | Active Comparator | Patients with asthma who are tolerant to aspirin and/or other NSAIDs and note sensitivity to alcoholic beverages |
|
| Aspirin Intolerant Asthma / AERD | Active Comparator | Patients with AERD who note sensitivity to alcoholic beverages |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Water | Dietary Supplement | Serum and urine markers will be obtained after drinking 5 oz of water |
|
| Measure | Description | Time Frame |
|---|---|---|
| 24 Hour Urinary Leukotriene-E4 (LTE4) | Urine LTE4 ng/mg Cr | 24 hour |
| Measure | Description | Time Frame |
|---|---|---|
| 24 Hour Urinary Prostaglandin-D2 (PGD2) metabolite | Urine PGD2 metabolite ng/mg Cr | 24 hour collection |
| Whole blood Activated Basophil Level | Proportion of activated basophils in whole blood after ingestion |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| BJ Ferrebee-Ghamandi, MHA | Contact | 434-243-1558 | Bjf8j@hscmail.mcc.virginia.edu |
| Name | Affiliation | Role |
|---|---|---|
| Spencer C Payne, MD | University of Virginia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Virginia | Recruiting | Charlottesville | Virginia | 22908 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24607050 | Background | Cardet JC, White AA, Barrett NA, Feldweg AM, Wickner PG, Savage J, Bhattacharyya N, Laidlaw TM. Alcohol-induced respiratory symptoms are common in patients with aspirin exacerbated respiratory disease. J Allergy Clin Immunol Pract. 2014 Mar-Apr;2(2):208-13.. doi: 10.1016/j.jaip.2013.12.003. | |
| 25213072 | Background |
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| ID | Term |
|---|---|
| D014867 | Water |
| ID | Term |
|---|---|
| D006878 | Hydroxides |
| D000468 | Alkalies |
| D007287 | Inorganic Chemicals |
| D000838 | Anions |
| D007477 |
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| Red wine | Dietary Supplement | Serum and urine markers will be obtained after drinking 5 oz of water |
|
| Polyphenolic Compounds | Dietary Supplement | Serum and urine markers will be obtained after consuming 100 mg of provinols powder |
|
| 2 hours after ingestion |
| Whole Blood Activated Eosinophil Level | Proportion of activated eosinophils in whole blood after ingestion | 2 hours after ingestion |
| Whole Blood tryptase | Level of tryptase concentration in whole blood | 2 hours after ingestion |
| Payne SC. Re: Alcohol-induced respiratory symptoms are common in patients with aspirin exacerbated respiratory disease. J Allergy Clin Immunol Pract. 2014 Sep-Oct;2(5):644. doi: 10.1016/j.jaip.2014.05.003. No abstract available. |
| Ions |
| D004573 | Electrolytes |
| D010087 | Oxides |
| D017601 | Oxygen Compounds |