Efficacy of Two Concentrations of Autologous Serum for the Treatment of Severe Dry Eye

Comparison of Autologous Serum 20% and Autologous Serum 50% for the Treatment of Severe Dry Eye

The purpose of this study is to compare the effects of autologous serum 20% and autologous serum 50% for the treatment of Severe Dry Eye Syndrome

To determine the difference between autologous serum 20% vs 50%, in terms of improvement of symptoms, improvement of ocular surface parameters and acceptable tolerability in patients with severe dry eye syndrome.

Inclusion Criteria:

• Man/woman ≥ 18 years old, able to freely give consent to participate in the study

• At least 1 of the following tests altered:

  • Ocular Surface Disease Index (OSDI) Test symptoms > 32
  • BUT ≤5 seconds
  • Oxford staining ≥ 3
  • Schirmer Test without anesthesia ≤ 5 mm

Exclusion Criteria:

• Sensitivity or known intolerance to any of the products used in the study
• Contraindication of venipuncture
• Story of ocular infections within the 6 previous months to study inclusion
• Any active ocular pathology other than Dry Eye Syndrome
• Use of contact lenses in the 3 previous months to study inclusion
• No pregnant or breastfeeding women is allowed to participate in the study. Childbearing potential women must use contraceptive means during the whole study.
• Participation in another clinical trial in the last 30 days before study inclusion