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The L-carnitine has demonstrated effects in the treatment of obesity mainly promoting the fat degradation during exercise.
A randomized, double-blind, placebo-controlled clinical trial will be carry out in 24 woman with body mass index ≥ 25 to 29.9 kg/m2. The patients will receive 1.5 g of L-Carnitine deluded in 250 ml of water or placebo before crossfit training, 5 times a week for 8 weeks. Before and after intervention the investigators evaluate: The body composition (body fat, lean body mass), arm muscle circumference, waist circumference, body weight and body mass index.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | Sucralose 1,5 g |
|
| L-Carnitine | Experimental | L- Carnitine 1,5 g |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| L-Carnitine | Drug | L-Carnitine oral solution 1.5 g diluted in 250 ml of water, before crossfit training, 5 times a week for 8 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| Body Fat | Calulated by Durnin formula. Results are reported in percentage and kg | 8 weeks |
| Lean body mass | Calulated by Durnin formula. Results are reported in percentage and kg | 8 weeks |
| Body Weight | Subject go up onto the scale and stand still over the center of the scale with body weight evenly distributed between both feet. Omron hbf-514c an digital scale and results are reported in kg with a decimal. | 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Arm muscle circumference | The right arm measure to the nearest centimeter with a measuring tape. Then, triceps skinfold thickness, an established measure of fat stores, measure to the nearest millimeter in the right arm using a skinfold caliper | 8 weeks |
| Waist circumference |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Diana M Hernández, PhD | Contact | +521 3314856584 | diana.hcorona@academicos.udg.mx | |
| Tonatiuh González, PhD | Contact | +521 3314664863 | drtonatiuhgh@live.com.mx |
| Name | Affiliation | Role |
|---|---|---|
| Diana M Hernández | University of Guadalajara | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centro Universitario de Tonalá | Tonalá | Jalisco | 45425 | Mexico |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23075564 | Background | Huang A, Owen K. Role of supplementary L-carnitine in exercise and exercise recovery. Med Sport Sci. 2012;59:135-142. doi: 10.1159/000341934. Epub 2012 Oct 15. | |
| 10861338 | Background | Villani RG, Gannon J, Self M, Rich PA. L-Carnitine supplementation combined with aerobic training does not promote weight loss in moderately obese women. Int J Sport Nutr Exerc Metab. 2000 Jun;10(2):199-207. doi: 10.1123/ijsnem.10.2.199. |
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| ID | Term |
|---|---|
| D001836 | Body Weight Changes |
| D050177 | Overweight |
| D009765 | Obesity |
| D001835 | Body Weight |
| ID | Term |
|---|---|
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
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| ID | Term |
|---|---|
| D002331 | Carnitine |
| C026285 | trichlorosucrose |
| ID | Term |
|---|---|
| D050337 | Trimethyl Ammonium Compounds |
| D000644 | Quaternary Ammonium Compounds |
| D000588 | Amines |
| D009930 | Organic Chemicals |
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| Sucralose | Dietary Supplement | Sucralose 1.5 g diluted in 250 ml of water, before crossfit training, 5 times a week for 8 weeks |
|
|
Flexible tape in the midpoint between the lowest rib and the iliac crest and is expressed in centimeters. Waist circumference was measured with a flexible tape in the midpoint between the lowest rib and the iliac crest and is expressed in centimeters. Waist circumference was measured with a flexible tape in the midpoint between the lowest rib and the iliac crest and is expressed in centimeters. |
| 8 weeks |
| Body Mass Index | Body mass divided by the square of the body height, and reported in units of kg/m2. | 8 weeks |
| 12514272 | Background | Hongu N, Sachan DS. Carnitine and choline supplementation with exercise alter carnitine profiles, biochemical markers of fat metabolism and serum leptin concentration in healthy women. J Nutr. 2003 Jan;133(1):84-9. doi: 10.1093/jn/133.1.84. |
| 21813919 | Background | Broad EM, Maughan RJ, Galloway S DR. Effects of exercise intensity and altered substrate availability on cardiovascular and metabolic responses to exercise after oral carnitine supplementation in athletes. Int J Sport Nutr Exerc Metab. 2011 Oct;21(5):385-97. doi: 10.1123/ijsnem.21.5.385. Epub 2011 Aug 3. |
| 22030098 | Background | Behrend AM, Harding CO, Shoemaker JD, Matern D, Sahn DJ, Elliot DL, Gillingham MB. Substrate oxidation and cardiac performance during exercise in disorders of long chain fatty acid oxidation. Mol Genet Metab. 2012 Jan;105(1):110-5. doi: 10.1016/j.ymgme.2011.09.030. Epub 2011 Oct 1. |
| 16826026 | Background | Kraemer WJ, Spiering BA, Volek JS, Ratamess NA, Sharman MJ, Rubin MR, French DN, Silvestre R, Hatfield DL, Van Heest JL, Vingren JL, Judelson DA, Deschenes MR, Maresh CM. Androgenic responses to resistance exercise: effects of feeding and L-carnitine. Med Sci Sports Exerc. 2006 Jul;38(7):1288-96. doi: 10.1249/01.mss.0000227314.85728.35. |
| D009750 | Nutritional and Metabolic Diseases |