The aim of our study is to evaluate the effect of coffee consumption on the risk of severe liver fibrosis in French patients with NASH.

Inclusion Criteria:

Any newly diagnosed case of NASH histologically proven graded according to SAF criteria

Or Metabolic syndrome defined by the IDF 2005 criteria:

• waist size> 94cm (men) or> 80cm (women)

• and the presence of at least two of the following criteria:

  • blood pressure: Systolic ≥ 130mmHg OR diastolic ≥ 85 mmHg OR antihypertensive treatment
  • Triglycerides ≥ 1.5g / L or lipid-lowering therapy
  • HDL cholesterol <0.4 g / L (men) or <0.5 g / L (women) or lipid-lowering therapy
  • fasting blood glucose:> 1 g / L or type 2 diabetes AND Hepatic steatosis diagnosed on liver imaging And liver fibrosis (diagnosed with a FibroScan> 6 KPa)

Exclusion Criteria:

• Age <18 years
• Viral hepatitis and other chronic liver diseases
• Alcohol consumption> 20g / day for women, 30g / day for men
• Liver biopsy or FibroScan dating more than 6 months before inclusion.
• History of bariatric surgery
• Serious psychiatric pathology (psychosis, dementia, severe depression) and patients under legal protection (tutelage, guardianship)
• Solid cancer or progressive hematology or <2 years (except basal cell carcinoma or localized squamous cell carcinoma)
• Severe and terminal chronic renal insufficiency (estimated GFR <30mL / min)
• Recent myocardial infarction <6 months

Non-Alcoholic Steatohepatitis