Endovascular arterial denervation (ED) is a minimally invasive technique which could reduce the occurrence of injury of visceral tissue or organs. As the principle of renal denervation (RDN), Radiofrequency energy delivered by a multi-electrode catheter to the celiac plexus over the anterolateral surface of the superior mesenteric artery (SMA) and the celiac axis. Damaged or partially damaged celiac plexus can achieve the effect of pain relief.

The multi-electrode catheter was consisted of six independent electrodes helically on a net structure, which could be set as the same energy and temperature for simultaneous multi-point ablation. A real-time monitoring capability also provided by the display.

Inclusion Criteria:

• 25 to 75 years
• severe cancer pain with the visual analogue scores of no less than 7

Exclusion Criteria:

• pregnant or intent to become pregnant within 1 year
• postural hypotension
• uncorrected coagulation dysfunction
• aortic aneurysm or dissection
• type 1 diabetes mellitus (T1DM)
• acute or severe systemic infection
• history of cerebral apoplexy or transient ischemic attack (TIA) in the past two weeks
• history of acute coronary syndrome in the past two weeks
• participants who are not suitable to be enrolled into the study assessed by the researchers