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To evaluate the correlation between pre-surgical 4DCT-ventilation imaging and post-surgical lung function.
To evaluate the correlation between pre-surgical 4-Dimensional Computed Tomography-ventilation (4DCT-ventilation) imaging and post-surgical lung function. To determine whether 4DCT-ventilation is a better predictor of post-surgical lung function than nuclear medicine imaging using pulmonary function tests (PFTs). To determine whether 4DCT-ventilation is a better predictor of post-surgical lung function than nuclear medicine imaging using quality of life (QOL) questionnaires. Evaluate cost-effectiveness of using 4DCT-ventialtion and VQ scans for pre-surgical assessment. To use longitudinal (pre and post-surgical) 4DCT-ventilation imaging to derive novel post-surgical prediction formulas.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 4DCT-ventilation | Experimental | The patient will undergo 4DCT imaging. The 4DCT imaging data along with image processing techniques will be used to generate a 4DCT-ventilation map. All surgical decisions will be based on the current standard of care imaging (VQ scans) and not on the 4DCT imaging results. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 4DCT-Ventilation | Diagnostic Test | 4DCT-ventilation is an imaging modality that provides superior image quality, reduced cost, and a faster imaging procedure compared to nuclear medicine VQ scans. |
| Measure | Description | Time Frame |
|---|---|---|
| Pre-Surgical Imaging and Post-Surgical Lung Function | Measure the correlation between pre-surgical 4-Dimensional Computed Tomography-ventilation (4DCT) imaging and post surgical lung function using a Percent Predicted Post-Operative Pulmonary Function Test (%PPO PFT). | Baseline visit to follow up visit, up to 9 months. |
| Measure | Description | Time Frame |
|---|---|---|
| Ability of %PPO PFTs | Use %PPO PFTs to determine if 4DCT-ventilation is a better predictor of post surgical lung function than nuclear medicine imaging | Start of study to end of study, up to 2 years |
| Quality of Life (QOL) |
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Inclusion Criteria:
Exclusion Criteria:
1. Patients getting a planned wedge resection as the only thoracic resectional procedure.
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| Name | Affiliation | Role |
|---|---|---|
| Bernard Jones | University of Colorado, Denver | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Colorado Denver | Aurora | Colorado | 80045 | United States | ||
| UCHealth Memorial Hospital |
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| ID | Term |
|---|---|
| D008175 | Lung Neoplasms |
| ID | Term |
|---|---|
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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Use QOL questionnaires to determine if 4DCT-ventilation is a better predictor of post surgical lung function than nuclear medicine imaging.
| Start of study to end of study, up to 2 years |
| Cost-Effectiveness | Determine the cost-effectiveness of 4DCT-ventialtion and VQ scans for pre-surgical assessment using Receiver Operator Characteristic (ROC) analysis. | Start of study to end of study, up to 2 years |
| Longitudinal Imaging Changes | Derive novel post-surgical prediction formulas using longitudinal 4DCT-ventilation imaging | Start of study to end of study, up to 2 years |
| Colorado Springs |
| Colorado |
| 80920 |
| United States |
| D008171 |
| Lung Diseases |
| D012140 | Respiratory Tract Diseases |