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The study aims to examine whether a single dose of modafinil (200mg, p.o.) can affect feedback-based learning and interference processing in healthy male subjects.
Based on previous animal and human research suggesting a catecholamine-mediated, potentially pro-cognitive, mechanism of action of modafinil, the present study seeks to explore effects of modafinil on feedback-based learning and interference processing in healthy subjects. To this end, the present randomized double-blind, between-subject, placebo-controlled pharmaco-fMRI experiment plans to determine the behavioral and neural effects of a single dose of p.o.modafinil (200mg) versus placebo on validated feedback-based learning and emotional/non-emotional cognitive conflict paradigms. To control for potential effects of pre-medication personality traits as well as effects of modafinil on subjective task performance, subjects will be administered pre-treatment assessing relevant personality traits and post-treatment assessments of meta-cognitive confidence estimation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| modafinil group | Experimental | a single dose of p.o. modafinil (200mg) |
|
| placebo group | Experimental | a single dose of p.o. placebo (200mg) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Modafinil Oral Tablet | Drug | modafinil 200mg |
| |
| Placebo Oral Tablet |
| Measure | Description | Time Frame |
|---|---|---|
| Neural processing during the interference processing | fMRI BOLD indices of neural processing in interference related brain regions will be compared between the treatment and placebo group. | 4h after treatment |
| Neural processing during feedback based learning | fMRI BOLD indices of neural processing learning related brain regions will be compared between the treatment and placebo group. | 4h after treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Behavioral interference performance - Response Time | Behavioral performance of interference performance for congruent and incongruent stimuli (picture vs word) will be compared between the treatment and placebo group. | 4h after treatment |
| Behavioral interference performance - Accuracy |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| School of Life Science and Technology | Recruiting | Chengdu | Sichuan | 611731 | China |
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| ID | Term |
|---|---|
| D000077408 | Modafinil |
| ID | Term |
|---|---|
| D001559 | Benzhydryl Compounds |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
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| Drug |
placebo 200mg |
|
Behavioral performance of interference in terms of accuracy for congruent and incongruent trials (picture vs word) will be compared between the treatment and placebo group. |
| 4h after treatment |
| Behavioral learning performance - Reaction time | Learning performance in terms of reaction times will be compared between the treatment and placebo group. | 4h after treatment |
| Behavioral learning performance - Accuracy | Learning performance in terms of accuracy (learning curve, trials to reach plateau) will be compared between the treatment and placebo group. | 4h after treatment |
| D006838 |
| Hydrocarbons |
| D009930 | Organic Chemicals |