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The purpose of this study is to determine the effects of dietary salt restriction on central hemodynamics and vascular function in men and women with salt resistant blood pressure.
Cardiovascular disease remains a major Public Health problem and is the leading cause of death in the US. Dietary sodium restriction is considered an important lifestyle modification for individuals with hypertension; however, there is controversy about the effects of dietary salt given that many individuals do not have "salt sensitive" blood pressure. Deleterious effects of salt on the vasculature may explain the finding that chronic DSR reduces the cardiovascular event rate by 25%despite only minor reductions in BP. It is not known whether dietary sodium restriction improves central pulsatile hemodynamics, known to be related to the development of left ventricular hypertrophy and heart failure risk, and whether the hypothesized improvements in central hemodynamics are similar in men & women. The purpose of this study is to determine the effects of dietary sodium restriction through dietary counseling on central hemodynamics and vascular function in men and women with salt resistant blood pressure.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dietary Sodium Restriction | Experimental | Daily habitual dietary sodium intake < 2000mg |
|
| Control | Sham Comparator | Routine habitual dietary sodium intake >3400mg |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dietary Sodium Restriction | Other | A registered dietician will counsel participants to reduce daily habitual dietary salt intake below 2000mg over 4 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| Reflected Pulse Wave Amplitude | Late systolic pulsatile load on the left ventricle represented by reflected pulse wave amplitude; assessed by echocardiography combined with applanation tonometry. | Change from baseline at 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Microvascular Function | Cutaneous microvascular dilatory response to local heating assessed by laser Doppler flowmetry coupled with intradermal microdialysis | Change from baseline at 4 weeks |
| Conduit Artery Endothelial Dependent Dilation |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| William B Farquhar, PhD | University of Delaware | Principal Investigator |
| David G Edwards, PhD | University of Delaware | Principal Investigator |
| Shannon Lennon, PhD | University of Delaware | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Kinesiology and Applied Physiology, University of Delaware | Newark | Delaware | 19713 | United States |
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| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
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| Control | Other | Participants will consume their routine habitual dietary sodium intake > 3400mg per day with regular pre determined check in phone calls from a registered dietician. |
|
Brachial artery flow mediated dilation assessed by duplex ultrasound
| Change from baseline at 4 weeks |
| Arterial Stiffness | Carotid - Femoral pulse wave velocity assessed by applanation tonometry | Change from baseline at 4 weeks |
| Forward pulse wave amplitude | Central hemodynamic assessment of the forward pulse wave amplitude assessed by echocardiography combined with applanation tonometry. | Change from baseline at 4 weeks |