This data collection project is intended to provide clinical outcomes data to engineering, marketing as well as fulfill the post market surveillance requirements of various regulatory authorities. The study will be a prospective and one-arm.

The Comprehensive® Shoulder System with Nano humeral component is a humeral prosthesis system intended for use in total or hemi shoulder arthroplasty surgery. Total shoulder arthroplasty consists of replacement of the humeral head and glenoid. Hemi-arthroplasty consists of replacement of only the humeral head.

This project is a prospective study including one-hundred and fifty (150) anatomic and hemi cases and 44 reverse shoulders collected from up to ten (10) sites. All potential study subjects will be required to participate in the Informed Consent process.

Inclusion Criteria:

• Non-inflammatory degenerative joint disease including osteoarthritis and avascular necrosis.
• Rheumatoid arthritis
• Revision where other devices or treatments have failed
• Correction of functional deformity.
• Difficult clinical management problems where other methods of treatment may not be suitable or may be inadequate
• Difficult clinical management problems where other methods of treatment may not be suitable or may be inadequate

Exclusion Criteria:

• Infection
• Sepsis
• osteomyelitis

Patients in need of an uncemented shoulder arthroplasty and who meet all of the inclusion and none of the exclusion criteria.