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It was previously suggested an improvement of graft survival in ABO/HLA incompatible kidney transplantation (KT) compared with HLA (human leukocyte antigen) incompatible transplantation. Here, the investigators would analyse clinical, biological and histological results of ABO/HLA incompatible kidney transplant recipients, comparing with ABO or HLA compatible kidney transplantation.
The investigators propose to analyze the clinical, biological and histological course of kidney function, but also to investigate the T and B cells population after KT in ABO incompatible, ABO/HLA incompatible and HLA incompatible kidney transplantation (1 and 7 years posttransplantation in each groups).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ABO/HLA incompatible KT | Experimental | Blood sampling for descriptive analysis of clinical, biological and histological of 12 ABO and HLA incompatible kidney transplantation (KT) |
|
| ABO incompatible KT | Experimental | Blood sampling for descriptive analysis of clinical, biological and histological of 28 ABO incompatible kidney transplantation |
|
| HLA incompatible KT | Experimental | Blood sampling for descriptive analysis of clinical, biological and histological of 20 HLA incompatible kidney transplantation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood sampling | Other | Descriptive analysis of clinical, biological and histological of 3 arms: ABO incompatible, HLA incompatible, and ABO/HLA incompatible kidney transplantation (1 and 5 years posttransplantation in each groups) |
| Measure | Description | Time Frame |
|---|---|---|
| Gene expression related to antibody mediated rejection | To determine expression of genes related to antibody mediated rejection (inflammation, and endothelial cell activation) by transcriptomic analyse (whole genome micro-array) on kidney biopsies | 1 year posttransplantation |
| Measure | Description | Time Frame |
|---|---|---|
| description of T subsets cells | to analyse of T subsets cells after Kidney transplantation in blood samples of patients by flow cytometry | 1 to 5 years posttransplantation |
| description of B subsets cells |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Arnaud DEL BELLO, MD PhD | University Hospital, Toulouse | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital | Toulouse | 31059 | France |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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to analyse of B subsets cells after Kidney transplantation in blood samples of patients by flow cytometry
| 1 to 5 years posttransplantation |
| description of lymphocytes rates | to analyse rates of lymphocytes after Kidney transplantation in blood samples of patients by flow cytometry | 1 to 5 years posttransplantation |
| Evolution of creatinine clearance | to analyse creatinine clearance in blood samples of patients after kidney transplantation | 1 to 5 years posttransplantation |
| Evolution of systematic annual kidney biopsies | To analyse the evolution of systematic annual kidney biopsies by microscopy | 1 to 5 years posttransplantation |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |