Impact of Anti-HLA Donor-specific Antibodies in ABO-incompatible Kidney Transplantation

Impact of Anti-HLA Donor-specific Antibodies in ABO-incompatible Kidney Transplantation

It was previously suggested an improvement of graft survival in ABO/HLA incompatible kidney transplantation (KT) compared with HLA (human leukocyte antigen) incompatible transplantation. Here, the investigators would analyse clinical, biological and histological results of ABO/HLA incompatible kidney transplant recipients, comparing with ABO or HLA compatible kidney transplantation.

The investigators propose to analyze the clinical, biological and histological course of kidney function, but also to investigate the T and B cells population after KT in ABO incompatible, ABO/HLA incompatible and HLA incompatible kidney transplantation (1 and 7 years posttransplantation in each groups).

Inclusion Criteria:

• Patient receiving a KT and followed at least one year in Toulouse Hospital
• Patient who have signed informed consent
• > 18 years old

Exclusion Criteria:

• Patient under protective measures
• Patients treated for cancer, infectious or immune disease by molecules that could interfere with lymphocyte populations : Interleukin 6 (IL6) blockers, Programmed cell death 1(PD1) and the cytotoxic T-lymphocyte-associated antigen 4 (CTL4) blockers.
• Immunosuppressive treatments withdrawal - Patient in chronic dialysis
• Ongoing pregnancy or pregnancy in the past year
• Past of splenectomy