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This study was designed as retrospective chart review to test our hypothesis whether there are the differences in inflammatory and anti-inflammatory mediators between asthmatic and ACOS patients with small airway obstruction, and COPD
The data including spirometry, lung volume, impulse oscillometry, sputum data, demographic characters within 6 months are collected for later analysis. Sputum supernatants and cytospins are used to determine inflammatory and anti-inflammatory responses in those patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Asthma with SAO+ | Asthmatic patients with RV/TLC > or = 40 |
| |
| Asthma with SAO- | Asthmatic patients with RV/TLC < 40 |
| |
| ACO | Asthmatic patients with smoking > or = 10 pack years who have persistent airway obstruction (post-BD FEV1/FVC < 0.7) or COPD patients who have bronchodilator (BD) reversibility (absolute increase in FEV1 > or = 200 ml and FEV1% > or =12% after BD) |
| |
| COPD | Patients with history of smoking > or = 10 pack year with post-BD FEV1/FVC < 0.7 and negative BD reversibility (absolute increase in FEV1 < 200 ml and FEV1% <12% after BD) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No any intervention | Other | No any intervention is applied to any groups in this study |
|
| Measure | Description | Time Frame |
|---|---|---|
| Lipoxin A4, , | Lipoxin A4 is measured in sputum supernatants by ELISA | 1 day (single time point) |
| Measure | Description | Time Frame |
|---|---|---|
| IL-33 | IL-33 is measured in sputum supernatants by ELISA | 1 day (single time point) |
| Thymic stromal lymphopoietin (TSLP) | TSLP is measured in sputum supernatants by ELISA |
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Inclusion Criteria:
Exclusion Criteria:
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Participants recruited from Asthma Clinics and OPD in Siriraj Hospital
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| Name | Affiliation | Role |
|---|---|---|
| Kittipong Maneechotesuwan, MD, PhD | Siriraj Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Siriraj Hospital | Bangkok Noi | Bangkok | 10700 | Thailand |
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| ID | Term |
|---|---|
| D001249 | Asthma |
| D029424 | Pulmonary Disease, Chronic Obstructive |
| D000080445 | Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome |
| ID | Term |
|---|---|
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
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Sputum cell pellets, sputum supernatants, and sputum cytospins
| 1 day (single time point) |
| D012130 |
| Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |