Small Airway Obstruction in Asthma, COPD, ACOS

Comparative Study on Sputum Anti-inflammatory Mediators in Patients With Asthma or Asthma and COPD Overlap (ACOS) Syndrome, and COPD

This study was designed as retrospective chart review to test our hypothesis whether there are the differences in inflammatory and anti-inflammatory mediators between asthmatic and ACOS patients with small airway obstruction, and COPD

The data including spirometry, lung volume, impulse oscillometry, sputum data, demographic characters within 6 months are collected for later analysis. Sputum supernatants and cytospins are used to determine inflammatory and anti-inflammatory responses in those patients.

Inclusion Criteria:

• Physician-diagnosed asthma, ACO, and COPD
• Their spirometric, IOS, lung volume, demographic data and sputum samples are available

Exclusion Criteria:

• Concomitant diseases requiring immunosuppressive therapy
• Being on treatments with NSAIDs, macrolides, statins