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The short-term advantages of minimally invasive colon resection have been well established in several randomized trials. A major factor in the development of morbidity is the surgical stress response with subsequent increased demand on the patient's reserves and immune competence. Although the advantage in term of stress response of laparoscopic surgery over open surgery has been widely reported, little is known about the role of Intracorporeal anastomosis.
In an attempt to evaluate the surgical stress response after totally laparoscopic right colectomy a comparative study has been designed.
Two surgical procedures will be evaluated:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intracorporeal | Experimental | Totally laparoscopic right colectomy with intracorporeal anastomosis |
|
| Extracorporeal | Active Comparator | Laparoscopic assisted right colectomy with extracorporeal anastomosis |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Laparoscopic right colectomy | Procedure | Laparoscopic right colectomy for colorectal cancer with a standard vascular dissection, performing the anastomosis with a side-to-side mechanical anastomosis fashioned intracorporeally versus extra corporeally |
| Measure | Description | Time Frame |
|---|---|---|
| interleukin 1 | change between time before surgery, 24 hours after surgery, 72 hours after surgery | |
| interleukin 6 | change between time before surgery, 24 hours after surgery, 72 hours after surgery | |
| tumor necrosis factor alpha | change between time before surgery, 24 hours after surgery, 72 hours after surgery | |
| adrenocorticotropic hormone | change between time before surgery, 24 hours after surgery, 72 hours after surgery | |
| cortisol | change between time before surgery, 24 hours after surgery, 72 hours after surgery | |
| insulin | change between time before surgery, 24 hours after surgery, 72 hours after surgery | |
| glucagon | change between time before surgery, 24 hours after surgery, 72 hours after surgery | |
| C-reactive protein | change between time before surgery, 24 hours after surgery, 72 hours after surgery | |
| growth hormone | change between time before surgery, 24 hours after surgery, 72 hours after surgery | |
| prolactin | change between time before surgery, 24 hours after surgery, 72 hours after surgery |
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Inclusion Criteria:
All elective laparoscopic right colectomy for cancer
Exclusion Criteria:
Urgent procedures Immune depressant therapy Immune depressant disease Post-operative Complications
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Naples Federico II | Naples | 80131 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33958669 | Derived | Milone M, Desiderio A, Velotti N, Manigrasso M, Vertaldi S, Bracale U, D'Ambra M, Servillo G, De Simone G, De Palma FDE, Perruolo G, Raciti GA, Miele C, Beguinot F, De Palma GD. Surgical stress and metabolic response after totally laparoscopic right colectomy. Sci Rep. 2021 May 6;11(1):9652. doi: 10.1038/s41598-021-89183-7. |
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| fibrinogen | change between time before surgery, 24 hours after surgery, 72 hours after surgery |