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| ID | Type | Description | Link |
|---|---|---|---|
| P50DC014664 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Deafness and Other Communication Disorders (NIDCD) | NIH |
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Stroke is the leading cause of adult disability in the United States, and aphasia is common following a stroke to the left hemisphere of the brain. Aphasia therapy can improve aphasia recover; however, very little is known about how different patients respond to different types of treatments.
The purpose of this study is to understand how the following factors influence an individual's response to aphasia treatment: 1) biographical factors (e.g., age, education, gender), 2) post-stroke cognitive/linguistic abilities and learning potential, and 3) the location and extent of post-stroke brain damage. We are also interested in understanding the kinds of treatment materials that should be emphasized in speech/language treatment.
Overall, the goal of the current research is to inform the clinical management of post-stroke aphasia by identifying factors that can predict how an individual will respond to different treatment methods.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Semantically focused treatment | Active Comparator | This treatment will focus on improving word finding and comprehension of information. |
|
| Phonologically focused treatment | Active Comparator | This treatment will focus on training speech sound production, targeting overall production abilities. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Semantically focused treatment | Behavioral | Tasks are as follows:
These are tasks used in clinical aphasia rehabilitation. |
| Measure | Description | Time Frame |
|---|---|---|
| Philadelphia Naming Test | Assesses the ability to name functional objects | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Julius Fridriksson, PhD, CCC-SLP | University of South Carolina | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical University of South Carolina | Charleston | South Carolina | 29425 | United States | ||
| University of South Carolina |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41203433 | Derived | Wilmskoetter J, Kristinsson S, Rangus I, Busby N, Rorden C, den Ouden D, Newman-Norlund R, Banister C, Riccardi N, Teghipco A, Newman-Norlund S, Fridriksson J, Bonilha L. Gene Expression-Based Lesion-Symptom Mapping: FOXP2 and Language Impairments after Stroke. J Neurosci. 2026 Jan 21;46(3):e0413252025. doi: 10.1523/JNEUROSCI.0413-25.2025. | |
| 36526425 | Derived | Busby N, Wilmskoetter J, Gleichgerrcht E, Rorden C, Roth R, Newman-Norlund R, Hillis AE, Keller SS, de Bezenac C, Kristinsson S, Fridriksson J, Bonilha L. Advanced Brain Age and Chronic Poststroke Aphasia Severity. Neurology. 2023 Mar 14;100(11):e1166-e1176. doi: 10.1212/WNL.0000000000201693. Epub 2022 Dec 16. |
| Label | URL |
|---|---|
| Study website | View source |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Apr 20, 2020 | Jan 29, 2021 | Prot_SAP_001.pdf |
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| ID | Term |
|---|---|
| D001037 | Aphasia |
| D020521 | Stroke |
| D000083242 | Ischemic Stroke |
| D001039 | Aphasia, Broca |
| D001041 | Aphasia, Wernicke |
| D018886 | Aphasia, Conduction |
| D000849 | Anomia |
| ID | Term |
|---|---|
| D013064 | Speech Disorders |
| D007806 | Language Disorders |
| D003147 | Communication Disorders |
| D019954 | Neurobehavioral Manifestations |
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|
| Phonologically focused treatment | Behavioral | Tasks are as follows:
These are tasks used in clinical aphasia rehabilitation. |
|
| Columbia |
| South Carolina |
| 29208 |
| United States |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |