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56 Parturients, aged 18-40 year, undergoing elective CS were randomly assigned to receive sequential intrathecal injection of fentanyl and hyperbaric bupivacaine at the same rate (normal sequential) NS or a rapid intrathecal injection of fentanyl followed by slow injection of hyperbaric bupivacaine (rapid sequential) RS. Time of first rescue analgesia, Dose of rescue analgesics, degree of postoperative pain, incidence of hypotension, hypotension duration, ephedrine dose, spinal anaesthesia related complications and failed block were recorded.
56 ASA physical status I, II Parturients, aged 18-40 year, undergoing elective CS were randomly assigned to receive sequential intrathecal injection of fentanyl and hyperbaric bupivacaine at the same rate through a 5ml syringe each (NS (normal sequential), n 28) or a rapid intrathecal injection of fentanyl through an insuline syringe followed by slow injection of hyperbaric bupivacaine through a 5ml syringe RS (rapid sequential), n 28). Onset of sensory block (T6 level), highest level of sensory block, time of first rescue analgesia, Dose of rescue analgesics, degree of postoperative pain by VAS 6H postoperative, Onset of motor block (Bromage scale0>3), duration of motor block (return to Bromage 0), incidence of hypotension, hypotension duration, ephedrine dose, spinal anaesthesia related complications as nausea, vomiting, pruritis, shivering and failed block were recorded.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| sequential intrathecal injection of fentanyl and bupivacaine | Active Comparator | intrathecal injection drug: fentanyl 25 μg (0.5 ml), IV,once drug: hyperbaric bupivacaine 0.5%10 mg IV,once both syringes were injected slowly sequentially |
|
| rapid sequential intrathecal injection of fentanyl and bupiva | Experimental | intrathecal injection drug: fentanyl 25 μg (0.5 ml), IV, injected rapidly and mixed by CSF, once drug: hyperbaric bupivacaine 0.5%10 mg IV injected slowly once. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| sequential intrathecal injection | Procedure | intrathecal injection of fentanyl and hyperbaric bupivacaine |
|
| Measure | Description | Time Frame |
|---|---|---|
| Duration of postoperative analgesia | technique provides prolonged post operative analgesia | 2-5 hours |
| Measure | Description | Time Frame |
|---|---|---|
| incidence of hypotension | note if hypotension occurs | 30 minutes |
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Inclusion Criteria:
Exclusion Criteria:
females undergoing CS
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| ID | Term |
|---|---|
| D005283 | Fentanyl |
| D000701 | Analgesics, Opioid |
| ID | Term |
|---|---|
| D010880 | Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D009294 | Narcotics |
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|
| hyperbaric bupivacaine | Drug | intrathecal injection of intrathecal bupivacaine |
|
|
| fentanyl | Drug | intrathecal injection of fentanyl |
|
|
| D002492 |
| Central Nervous System Depressants |
| D045505 | Physiological Effects of Drugs |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
| D000700 | Analgesics |
| D018689 | Sensory System Agents |
| D018373 | Peripheral Nervous System Agents |
| D002491 | Central Nervous System Agents |
| D045506 | Therapeutic Uses |