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This study aims to compare the effects of transcranial direct current stimulation on the clinical and cognitive function in patients with chronic migraine.
The patients will be randomized into 1 of 3 groups: active tDCS for 15 minutes, active tDCS for 15 minutes, with an interval of 20 minutes and more 15 minutes os stimulation, sham tDCS for 15 minutes. The tDCS will be applied for 10 days over 2 weeks.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| active tDCS | Active Comparator | Active tDCS for 15 minutes for 10 days over 2 weeks. Intensity: 2 milliampere. Placement: anode - left DLPFC; cathode - right supraorbital region |
|
| active tDCS with interval | Experimental | Active tDCS for 15 minutes, interval of 20 minutes and more 15 minutes for 10 days over 2 weeks. Intensity: 2 milliampere. Placement: anode - left DLPFC; cathode - right supraorbital region |
|
| sham tDCS | Sham Comparator | Sham tDCS for 15 minutes for 10 days over 2 weeks. The stimulation is non-active. Placement: anode - left DLPFC; cathode - right supraorbital region |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| tDCS | Other | Transcranial Current Stimulation equipment consists of an ammeter (measured with current intensity), a potentiometer (voltage controller between the electrodes), a generator (two 9-volt batteries) and two electrodes (anode and cathode). The direct low-amplitude currents released by the electrodes reach the cortex and modify the neuronal potentials. |
| Measure | Description | Time Frame |
|---|---|---|
| Migraine Disability Assessment - MIDAS | Change in perform activities of daily living associate to migraine assessed on the Migraine Disability Assessment - MIDAS. | "before treatment", "after treatment - up to 2 weeks " and "up to 1 month after the last day of treatment" |
| Measure | Description | Time Frame |
|---|---|---|
| Headache Impact Test - HIT-6 | Change in quality of life associate to migraine assessed on the Headache Impact Test-6 (HIT-6) | "before treatment", "after treatment - up to 2 weeks " and "up to 1 month after the last day of treatment" |
| Wechsler Intelligence Scale Letters |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Renata Aranha | Federal University of Paraiba | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Federal University of Paraiba | João Pessoa | ParaÃba | Brazil |
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| ID | Term |
|---|---|
| D008881 | Migraine Disorders |
| D019954 | Neurobehavioral Manifestations |
| ID | Term |
|---|---|
| D051270 | Headache Disorders, Primary |
| D020773 | Headache Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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The patients will be randomized into 1 of 3 groups:
group A: active tDCS for 15 minutes, group B: active tDCS for 15 minutes, with an interval of 20 minutes and group C: more 15 minutes os stimulation, sham tDCS for 15 minutes.
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|
Change in cognitive ability assessed on the Wechsler Adult Intelligence Scale Letters |
| "before treatment", "after treatment - up to 2 weeks " and "up to 1 month after the last day of treatment" |
| Wechsler Intelligence Scale Numbers Test | Change in cognitive ability assessed on the Wechsler Adult Intelligence Scale Numbers Test | "before treatment", "after treatment - up to 2 weeks " and "up to 1 month after the last day of treatment" |
| Hayling's Test Hayling's Test | Change in operational memory assessed on the Hayling's Test Evaluate operational memory | "before treatment", "after treatment - up to 2 weeks " and "up to 1 month after the last day of treatment" |
| Trail Making Test part B | Change in executive functions assessed on the Trail Making Test part B | "before treatment", "after treatment - up to 2 weeks " and "up to 1 month after the last day of treatment" |
| Salthouse Visual Patterns and Lyrics | Change in visual processing speed assessed on the Salthouse Visual Patterns and Lyrics | "before treatment", "after treatment - up to 2 weeks " and "up to 1 month after the last day of treatment" |
| Nine Hole Peg Test | Change in the motor processing speed assessed on the Nine Hole Peg Test | "before treatment", "after treatment - up to 2 weeks " and "up to 1 month after the last day of treatment" |
| Paced Auditory Serial Addition Task | Change in selective attention assessed on the Paced Auditory Serial Addition Task | "before treatment", "after treatment - up to 2 weeks " and "up to 1 month after the last day of treatment" |
| Concentrated Attention Test | Change in selective attention assessed on the Concentrated Attention Test | "before treatment", "after treatment - up to 2 weeks " and "up to 1 month after the last day of treatment" |
| Visual Attention Test (Attention Matrices) | Change in selective attention assessed on the Visual Attention Test (Attention Matrices) | "before treatment", "after treatment - up to 2 weeks " and "up to 1 month after the last day of treatment" |
| Montreal Cognitive Assessment | Change in cognition assessed on the Montreal Cognitive Assessment | "before treatment", "after treatment - up to 2 weeks " and "up to 1 month after the last day of treatment" |
| Side Effects Questionnaire | adverse effects assessment | "every day for up to 2 weeks" |
| D009422 | Nervous System Diseases |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |