Alterations in Cognitive Function and Cerebral Blood Flow After Conversion From Calcineurin Inhibitors (CNIs) to Everolimus

Alterations in Cognitive Function and Cerebral Blood Flow After Conversion From Calcineurin Inhibitors to Everolimus

The purpose of this study is to learn if changing from Tacrolimus to Everolimus will improve cognitive function by having less effect on brain blood flow.

Inclusion Criteria:

• English speaking
• able to sign informed consent
• able to arrange transportation to and from study site
• without acute stroke, concussion or traumatic brain injury
• without acute medical issues at the time of participation
• At least 12 weeks post Kidney transplant surgery

Exclusion Criteria:

• are claustrophobic or have other contra-indication for magnetic resonance imaging (MRI)
• have hearing or visual impairment
• are unable to read, write, speak or understand English
• have uncontrolled psychosis or seizure disorder or are currently using antipsychotics or anti-epileptics
• taking Envarsus at the time of recruitment