Vancomycin Dosage Adjustment for MRSA Infections

A Comparative Efficacy Study of Vancomycin Dosage Adjustment by Equation-based Method and Vancomycin Trough Concentration Method for Treatment of Infections Caused by Methicillin Resistant Staphylococcus Aureus

An open-label randomized controlled trial to compare two vancomycin dosage adjustment methods

An open-label randomized controlled trial to compare two vancomycin dosage adjustment methods; a vancomycin trough concentration method and a equation-based method.

Inclusion Criteria:

1. Thai hospitalized patients, age>18 years
2. Require vancomycin therapy ≥ 3 days
3. Documented MRSA infection including pneumonia, bacteremia, intra-abdominal infection or skin and soft tissue infection
4. Have been checked for serum creatinine within 48 hours and serum albumin within 7 days prior to enrollment
5. Received an appropriate loading dose of vancomycin
6. Have been treated with an appropriate maintenance dose of vancomycin
7. Willing to sign an informed consent

Exclusion Criteria:

1. CrCl< 10 ml/min or receiving renal replacement therapy
2. Pregnancy or lactation
3. Actual BW> 90 kg
4. Serum albumin <2 g/dl
5. Having an active cancer or receiving chemotherapy
6. Hx of vancomycin allergy