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The aim was the comparison of the perioperative time courses of matrix metalloproteinase-9 (MMP-9) and its inhibitor (TIMP-1) during elective carotid artery stenting (CAS). The investigators used a matched, historical carotid endarteriectomy group as controls. Blood samples at four time points: T1: preoperative; T2: 60 minutes after stent insertion; T3: first postoperative morning; and T4: third postoperative morning. Plasma was isolated from heparin anticoagulated blood samples by low speed centrifugation at 4 °C, and stored at -80 °C until analyzed in a single batch at the end of the study. Plasma concentrations of MMP-9 and TIMP-1 were expressed as ng/ml.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Carotid artery stenting | Patients undergo carotid artery stenting. |
| |
| Carotid endarterectomy | Patients receive elective carotid endarterectomy. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Carotid artery stenting | Procedure | Patient undergo elective carotid artery stenting. In this patient group blood sampling was performed at three time points: T1, at the time of the insertion of the arterial line; T2, 60 min after stent insertion; and T3: the first postoperative morning. |
| Measure | Description | Time Frame |
|---|---|---|
| Plasma MMP-9 concentrations | Plasma is isolated from heparin-anticoagulated blood samples by low speed centrifugation at 4 °C. MMP-9 levels were measured with quantitative sandwich enzyme-linked immunosorbent assay. | 4 days |
| Plasma TIMP-1 concentrations | Plasma is isolated from heparin-anticoagulated blood samples by low speed centrifugation at 4 °C. TIMP-1 levels were measured with quantitative sandwich enzyme-linked immunosorbent assay. | 4 days |
| Measure | Description | Time Frame |
|---|---|---|
| MMP-9/TIMP-1 ratio | MMP-9/TIMP-1 is calculated from the measured plasma MMP-9 and TIMP-1 concentrations | 4 days |
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Inclusion Criteria:
elective carotid artery surgery
Exclusion Criteria:
Malignant diseases, inflammatory and systemic autoimmune disorders, psychiatric disorders and previous debilitating stroke
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Diagnosed carotid artery stenosis
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| Name | Affiliation | Role |
|---|---|---|
| Gábor Woth, MD, PhD | Department of Anaesthesiology and Intensive Therapy, Medical School, University of Pécs | Principal Investigator |
| Bálint Nagy, MD, PhD | Department of Anaesthesiology and Intensive Therapy, Medical School, University of Pécs | Principal Investigator |
| Diana Mühl, MD, PhD | Department of Anaesthesiology and Intensive Therapy, Medical School, University of Pécs | Study Director |
| János Lantos, PhD | Department of Surgical Research and Techniques, Medical School, University of Pécs, | Principal Investigator |
| Ferenc Kövér, MD | Department of Neurosurgery, Medical School, University of Pécs, | Principal Investigator |
| Lajos Bogár, MD, DsC | Department of Anaesthesiology and Intensive Therapy, Medical School, University of Pécs | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anaesthesiology and Intensive Therapy, Medical School, University of Pécs | Pécs | Baranya | H-7624 | Hungary |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27121520 | Background | Nagy B, Woth G, Merei A, Nagy L, Lantos J, Menyhei G, Bogar L, Muhl D. Perioperative time course of matrix metalloproteinase-9 (MMP-9), its tissue inhibitor TIMP-1 & S100B protein in carotid surgery. Indian J Med Res. 2016 Feb;143(2):220-6. doi: 10.4103/0971-5916.180212. | |
| 30157791 | Derived | Merei A, Nagy B, Woth G, Lantos J, Kover F, Bogar L, Muhl D. Comparison of the perioperative time courses of matrix metalloproteinase-9 (MMP-9) and its inhibitor (TIMP-1) during carotid artery stenting (CAS) and carotid endarterectomy (CEA). BMC Neurol. 2018 Aug 29;18(1):128. doi: 10.1186/s12883-018-1133-1. |
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| ID | Term |
|---|---|
| D016893 | Carotid Stenosis |
| D015427 | Reperfusion Injury |
| ID | Term |
|---|---|
| D002340 | Carotid Artery Diseases |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| ID | Term |
|---|---|
| D016894 | Endarterectomy, Carotid |
| ID | Term |
|---|---|
| D004691 | Endarterectomy |
| D014656 | Vascular Surgical Procedures |
| D013504 | Cardiovascular Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
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Blood
|
| Carotid endarterectomy | Procedure | Patient undergo elective carotid endarterectomy. Group samples were collected at the following four time points: T1, at the time of the insertion of the arterial line; T2, 60 min after cross-clamp release; T3, the first postoperative morning; and T4, the third postoperative morning. A matched subgroup of patients from the previously obtained data served as a historical control. |
|
| D009422 | Nervous System Diseases |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |