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Propylene glycol/Glycerol intake is increasingly popular. The propylene glycol/glycerol intake effects on cardiorespiratory function are unknown.
Background. Propylene glycol/Glycerol intake is increasingly popular. The propylene glycol/glycerol intake effects on cardiorespiratory function are unknown. Weaning of propylene glycol/glycerol could allows a quick clearance of propylene glycol/glycerol from the body, with subsequent recovery of cardiorespiratory function.
Specific aim of the research. This research proposal tests the following hypothesis regarding the reversibility of propylene glycol/glycerol and nicotine intake:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Nicotine free intake | Experimental | The participant will wean off nicotine during five days before the experimental session. At the start of the experimental session, participants will be exposed to acute propylene glycol/glycerol (mix 50:50) intake. |
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| Nicotine intake | Experimental | The participant will pursuit his regular nicotinic propylene/glycerol intake five days before the experimental session. At the start of the experimental session, participants will be exposed to acute propylene glycol/glycerol/nicotine (mix 50:50) intake. |
|
| Cessation intake | Experimental | The participant will completely stop his regular nicotinic propylene/glycerol intake during five days before the session. At the start of the experimental session, participants will mimick intake with the device turns off. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nicotine free intake | Other | The participant will wean off nicotine during five days before the experimental session. At the start of the experimental session, participants will be exposed to acute propylene glycol/glycerol (mix 50:50) intake. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in cardiorespiratory function | Continuous monitoring of cardiorespiratory function | 4 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Change in serum and urine proteomics profiles | Serum and urine proteomics | 1 hour |
| Measure | Description | Time Frame |
|---|---|---|
| Change in serum and exhaled breath condensate metabolomics profiles | Serum and exhaled breath condensate metabolomics | 1 hour |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Philippe van de Borne, MD, PhD | Université Libre de Bruxelles | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Erasme Hospital | Brussels | Anderlecht | 1070 | Belgium |
The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request
Immediately following publication. No end date.
Any purpose Proposals should be directed to martin.chaumont@ulb.ac.be
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP_ICF | Yes | Yes | Yes | Study Protocol, Statistical Analysis Plan, and Informed Consent Form | Jan 15, 2018 | Feb 27, 2018 | Prot_SAP_ICF_000.pdf |
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| ID | Term |
|---|---|
| D055370 | Lung Injury |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D013898 | Thoracic Injuries |
| D014947 | Wounds and Injuries |
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| Nicotine intake | Other | The participant will pursuit his regular nicotinic propylene/glycerol intake five days before the experimental session. At the start of the experimental session, participants will be exposed to acute propylene glycol/glycerol (mix 50:50) intake. |
|
| Cessation intake | Other | The participant will completely stop his regular nicotinic propylene/glycerol intake during five days before the session. At the start of the experimental session, participants will mimick intake with the device turns off. |
|