Feasibility of Centralized Therapeutic Drug Monitoring of Fluoroquinolones in Multi-Drug Resistant Tuberculosis Patients

Prospective Evaluation of impRoving Fluoroquinolone Exposure Using Centralized Tdm in TB Patients

Observational, multi-centre, prospective study to investigate the feasibility of centralized TDM of moxifloxacin and levofloxacin in MDR-TB patients by determining turn-around time between sampling and receiving dosing advice.

In addition, the effect of TDM will be evaluated by comparing treatment results of prospective patients receiving TDM with historical controls without TDM.

Inclusion Criteria:

• Pulmonary MDR-TB
• Sputum smear and sputum culture positive at baseline
• Oral administration of either moxifloxacin or levofloxacin
• Written informed consent (for use of the medical data)

Exclusion Criteria:

• Pregnancy or breast feeding