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The main purpose of this study is to compare the effects of high intensity interval training and moderate intensity continuous training on inflammatory profile and metabolic markers, after 8 weeks of intervention trial in obese women.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control group (CTr) | Experimental | No counseling or nutritional therapy and no exercise |
|
| Moderate intensity continuous training (MICT) | Experimental | Follow-up during a period of 8 weeks of supervised ergometer-based moderate-intensity continuous training based on HRmax (MICT). MICT:
|
|
| High Intensity Interval Training (HIIT) | Experimental | Procedures: Follow-up during a period of 8 weeks of supervised ergometer-based high intensity interval training based on HRmax (HIIT). HIIT:
|
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CTR | Other | no counseling or nutritional therapy and no exercise |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Inflammatory profile | C-reactive protein (CRP) (mg/dL) | 8 weeks (baseline to 8 week follow-up assessment) |
| Inflammatory profile | Interleukin 6 (IL-6) (ng/mL) | 8 weeks (baseline to 8 week follow-up assessment) |
| Inflammatory profile | Interleukin 10 (IL-10) pg/mL, Interleukin-1B (IL-1B) pg/mL, Tumor Necrosis Factor (TNF)-α (pg/mL), Adiponectin (pg/mL), Monocyte chemoattractant protein 1 (MCP-1) (pg/mL), Leptin (pg/mL) | 8 weeks (baseline to 8 week follow-up assessment) |
| Measure | Description | Time Frame |
|---|---|---|
| Body Composition and Anthropometric profile | Body weight (kg), Fat free mass (FFM) (kg), fat mass (FM) (kg) | 8 weeks (baseline to 8 week follow-up assessment) ] |
| Body Composition and Anthropometric profile |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Vivian M M SUEN, PhD | fmrp usp | Study Director |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D024821 | Metabolic Syndrome |
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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Three-arm parallel, Randomized-controlled study
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Outcome Assessors involved in data analysis will not be aware of the arm to which the participants were allocated (single-blinded masking)
| MICT |
| Other |
no counseling or nutritional therapy. 8 weeks of individualized and supervised ergometer-based moderate continuous intensity training (MICT). |
|
| HIIT | Other | no counseling or nutritional therapy. 8 weeks of individualized and supervised ergometer-based high intensity interval training (HIIT) |
|
Body Mass Index (BMI) (kg/m²)
| 8 weeks (baseline to 8 week follow-up assessment) ] |
| Body Composition and Anthropometric profile | Waist circumference (cm), hip circumference (cm) | 8 weeks (baseline to 8 week follow-up assessment) ] |
| Body Composition and Anthropometric profile | Body Adiposity Index (BAI) and Waist-To-Hip Ratio (WHR) | 8 weeks (baseline to 8 week follow-up assessment) ] |
| Insulin sensitivity | Insulin sensitivity was estimated using homeostasis model assessment index (HOMA) | 8 weeks (baseline to 8 week follow-up assessment) ] |
| Lipid profile | Lipid profile was assessed by measuring levels of triglyceride (TG) (mg/dL), total cholesterol (CT) (mg/dL), high-density lipoprotein cholesterol (HDL-C) (mg/dL) and low-density lipoprotein cholesterol (LDL-C) (mg/dL) | 8 weeks (baseline to 8 week follow-up assessment) ] |
| Cardiorespiratory Fitness (CRF) | CRF was assessed by measuring Peak Oxygen uptake (VO2peak) mL/kg/min | 8 weeks (baseline to 8 week follow-up assessment) ] |
| Blood Pressure (BP) | Blood Pressure (mmHg) was assessed by measuring rest levels of Systolic blood pressure (SBP) and Diastolic blood pressure (DBP) | 8 weeks (baseline to 8 week follow-up assessment) ] |
| Resting Energy Expenditure (REE) | Resting Energy Expenditure (kcal/day) was measured through indirect calorimetry with an open-circuit ventilated-hood system Substrate oxidation rate was calculated from VO2 (mL/min) and VCO2 (mL/min) | 8 weeks (baseline to 8 week follow-up assessment) ] |
| Substrate oxidation rate | Substrate oxidation rate was calculated from VO2 (mL/min) and VCO2 (mL/min) | 8 weeks (baseline to 8 week follow-up assessment) ] |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D010335 | Pathologic Processes |