Uterine Microbiome in Women with Repeated Implantation Failure and Normal Fertile Women

Comparative Analysis of the Uterine Microbiome in Women with Repeated Implantation Failure and Normal Fertile Women

Characterization of the uterine microbiome in women with repeated implantation failure as well as in normal fertile women.

In the midluteal phase of the cycle, a vaginal swab and endometrial biopsy will be obtained.

Inclusion Criteria:

• Women between their 18th and 40th birthdays (max 39 years and 364 days at the day of signing the informed consent)
• Able to understand, read and speak Dutch and hence to provide written and oral informed consent
• Negative serological tests for human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), Rapid plasma reagin (RPR) for syphilis

Exclusion Criteria:

• Hormonal contraception in current cycle
• Presence of intra-uterine device
• Antibiotic treatment in the current cycle