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Intervention cross-over study during which participants receive standardized amounts of aronia berry tablets or placebo for three months, then wash out for three months, then aronia tablets or placebo for three months. The potential health effects are investigated. Following parameters are measured before and after each period of tablet intake: 1) Blood pressure, 2) Lipid fractions, 3) Testosterone, 4) Phase II markers, 5) HbA1c, 6) HSCRP, 7) F2-isoprostanes, and 8) semen quality.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Aroia | Active Comparator |
| |
| Placebo | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Aronia, washout and then placebo | Dietary Supplement | Three tablets three times à day for three months then washout for three months, then three placebo tablets three times à day for three months. Blood samples and semen samples collected before and after each period of tablet intake. |
| Measure | Description | Time Frame |
|---|---|---|
| Cholesterol | HDL, LDL and total cholesterol in mmol/L | 9 months |
| Measure | Description | Time Frame |
|---|---|---|
| Phase II enzyme activity | Glutathion in U/mL | 9 months |
| Phase II enzyme activity | Superoxid dismutase (SOD) in U/mL | 9 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre of Andrology & Fertility Clinic, Department D, Odense University Hospital | Odense | DK-5000 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36615174 | Background | Sangild J, Faldborg A, Schousboe C, Fedder MDK, Christensen LP, Lausdahl AK, Arnspang EC, Gregersen S, Jakobsen HB, Knudsen UB, Fedder J. Effects of Chokeberries (Aronia spp.) on Cytoprotective and Cardiometabolic Markers and Semen Quality in 109 Mildly Hypercholesterolemic Danish Men: A Prospective, Double-Blinded, Randomized, Crossover Trial. J Clin Med. 2023 Jan 3;12(1):373. doi: 10.3390/jcm12010373. |
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|
| Placebo, washout and then aronia | Dietary Supplement | Three tablets three times à day for three months, then washout for three months, then three aronia tablets three times à day for three months. Blood samples and semen samples collected before and after each period of tablet intake. |
|
| Phase II enzyme activity | Catalase (CAT) in U/mL | 9 months |
| Isoprostanes | Peroxidation of fatty acids measured in U/mL | 9 months |
| Semen quality | Sperm count in million/mL | 9 months |
| Semen quality | Motility in percent | 9 months |
| Semen quality | DNA fragmentation in percent | 9 months |
| Blood pressure | Systolic and diastolic blood pressure in mmHg | 9 months |
| High Sensitivity C reactive protein | Acute phase reactant in mg/L | 9 months |